Preparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions
This is a preliminary study utilizing drug targeting approach for developing sildenafil citrate (SFC) pulmonary delivery system, a first – line for pulmonary arterial hypertension (PAH) treatment and hence reducing the dose and the side effects. The closed melt method was employed for preparing SFC – solid lipid microparticles dispersions (SFC – SLMDs), a non – solvent technique aid in the production of drug – matrix dispersions with sustained release properties. Glyceryl behenate (GB) (Compritol® 888 ATO) was used as the retarding matrix and the results shown that as its ratio increase there was a decrease in the fine particle fraction, an increase in the drug content and a prolong drug release pattern. The best model fit the release data was Higuchi – Matrix model which indicates drug diffusion – controlled releasing mechanism. Thus, inhaled SFC – SLMDs dry powder will improve PAH treatment via drug localization at low doses and reducing the administration frequency.
