Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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This is a preliminary study utilizing drug targeting approach for developing sildenafil citrate (SFC) pulmonary delivery system, a first -line for pulmonary arterial hypertension (PAH) treatment and hence reducing the dose and the side effects. The closed melt method was employed for preparing SFC -solid lipid microparticles dispersions (SFC -SLMDs), a nonsolvent technique aid in the production of drug -matrix dispersions with sustained release properties. Glyceryl behenate (GB) (Compritol® 888 ATO) was used as the retarding matrix and the results shown that as its ratio increase there was a decrease in the fine particle fraction, an increase in the drug content and a prolong drug release pattern. The best model fit the release data was Higuchi -Matrix model which indicates drug diffusion -controlled releasing mechanism. Thus, inhaled SFC -SLMDs dry powder will improve PAH treatment via drug localization at low doses and reducing the administration frequency.
A. A.Yas. 2014. \u201cPreparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B5): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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Total Score: 102
Country: Iraq
Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine
Authors: A. A.Yas, Ali Al - Jipouri (PhD/Dr. count: 0)
View Count (all-time): 150
Total Views (Real + Logic): 4451
Total Downloads (simulated): 2317
Publish Date: 2014 10, Sat
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This is a preliminary study utilizing drug targeting approach for developing sildenafil citrate (SFC) pulmonary delivery system, a first -line for pulmonary arterial hypertension (PAH) treatment and hence reducing the dose and the side effects. The closed melt method was employed for preparing SFC -solid lipid microparticles dispersions (SFC -SLMDs), a nonsolvent technique aid in the production of drug -matrix dispersions with sustained release properties. Glyceryl behenate (GB) (Compritol® 888 ATO) was used as the retarding matrix and the results shown that as its ratio increase there was a decrease in the fine particle fraction, an increase in the drug content and a prolong drug release pattern. The best model fit the release data was Higuchi -Matrix model which indicates drug diffusion -controlled releasing mechanism. Thus, inhaled SFC -SLMDs dry powder will improve PAH treatment via drug localization at low doses and reducing the administration frequency.
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