Preparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions

Preparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions

A. A.Yas

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Ali Al - Jipouri

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α University of Tikrit

Preparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions

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Abstract

This is a preliminary study utilizing drug targeting approach for developing sildenafil citrate (SFC) pulmonary delivery system, a first -line for pulmonary arterial hypertension (PAH) treatment and hence reducing the dose and the side effects. The closed melt method was employed for preparing SFC -solid lipid microparticles dispersions (SFC -SLMDs), a nonsolvent technique aid in the production of drug -matrix dispersions with sustained release properties. Glyceryl behenate (GB) (Compritol® 888 ATO) was used as the retarding matrix and the results shown that as its ratio increase there was a decrease in the fine particle fraction, an increase in the drug content and a prolong drug release pattern. The best model fit the release data was Higuchi -Matrix model which indicates drug diffusion -controlled releasing mechanism. Thus, inhaled SFC -SLMDs dry powder will improve PAH treatment via drug localization at low doses and reducing the administration frequency.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

A. A.Yas. 2014. \u201cPreparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B5): .

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GJMR Volume 14 Issue B5
Pg. 1- 5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

closed melt method dry powder inhaler glyceryl behenate sildenafil citrate solid lipid microparticles dispersions

Submission ReceivedDecember 14, 2013
Peer Review Double Blind
Handling Editor
Accepted January 2, 2014
Published January 15, 2014

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October 25, 2014

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Article Matrices

Total Score: 102

Country: Iraq

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: A. A.Yas, Ali Al - Jipouri (PhD/Dr. count: 0)

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