Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery

1
Thimmaraju D R
Thimmaraju D R
2
Dr. Abdul Nasir Kurnool
Dr. Abdul Nasir Kurnool
1 Adichunchanagiri College of Pharmacy

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Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery Banner
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The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Thimmaraju D R. 2020. \u201cProniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 252
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v1.2

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July 27, 2020

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English

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The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.

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Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery

Thimmaraju D R
Thimmaraju D R Adichunchanagiri College of Pharmacy
Dr. Abdul Nasir Kurnool
Dr. Abdul Nasir Kurnool

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