Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.
Thimmaraju D R. 2020. \u201cProniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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Total Score: 107
Country: India
Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine
Authors: Thimmaraju D R, Dr. Abdul Nasir Kurnool (PhD/Dr. count: 1)
View Count (all-time): 137
Total Views (Real + Logic): 2245
Total Downloads (simulated): 1117
Publish Date: 2020 07, Mon
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The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.
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