Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery
The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.
