Quality Guarantee in Parenteral Nutrition: Implementation of Chemical and Microbiological Quality Controls

Quality Guarantee in Parenteral Nutrition: Implementation of Chemical and Microbiological Quality Controls

Carolina Salas

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Daisy Miranda

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Giannina Faundez

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Daniel Navea

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Quality Guarantee in Parenteral Nutrition: Implementation of Chemical and Microbiological Quality Controls

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Abstract

In the preparation of a parenteral nutrition (NP) is always present the risk of errors in the addition or omission of nutrients (chemical composition) or rupture of strict aseptic technique (microbiological quality). Both the Pharmacopoeia and national legislation suggest basic qualitative controls of areas, so the objective of this study is to implement additional analytical and microbiological quality controls, to verify the preparation process, as well as to ensure chemical stability and absence of contamination. For chemical control it included glucose, sodium, calcium, magnesium, phosphorus, potassium and chlorine in 40 samples in the Cobas®B221 and Vitros®4600 equipment, pH, and microbiological control, through NP culture in blood agar after preparation and after 5 days of storage. At day 0, the concentrations of glucose, sodium and calcium correlate with the theoretical concentration. On day 5 of storage glucose, sodium, calcium, magnesium, phosphorus, potassium and chlorine correlated with the theoretical concentration on day 0. No growth of microorganisms was observed in any sample. It is established as a chemical control of elaboration glucose, sodium and calcium; and as chemical stability controls glucose, sodium, calcium, magnesium, phosphorus, potassium and chlorine, maintaining its sterility.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Carolina Salas. 2018. \u201cQuality Guarantee in Parenteral Nutrition: Implementation of Chemical and Microbiological Quality Controls\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 18 (GJMR Volume 18 Issue B4).

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GJMR Volume 18 Issue B4

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-B Classification NLMC Code: QW 4

Submission ReceivedDecember 14, 2017
Peer Review Double Blind
Handling Editor
Accepted January 1, 2018
Published January 15, 2018

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v1.2

Issue date

October 23, 2018

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Article Matrices

Total Score: 124

Country: Chile

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Carolina Salas, Daisy Miranda, Giannina Faundez, Daniel Navea (PhD/Dr. count: 0)

View Count (all-time): 166

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Total Downloads (simulated): 1503

Publish Date: 2018 10, Tue

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Total Views: 3165

Total Downloads: 1503

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