Reducing Topical Mometasone Furoate Doses by Applying Hyaluronic Acid as a Skin Penetration Enhancer

Reducing Topical Mometasone Furoate Doses by Applying Hyaluronic Acid as a Skin Penetration Enhancer

Usama Farghaly Aly

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Khaled Aly Khaled

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Doaa Amal Tawfik

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α Minia University

Reducing Topical Mometasone Furoate Doses by Applying Hyaluronic Acid as a Skin Penetration Enhancer

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Abstract

The objective of the present study was to investigate the possibility to add hyaluronic acid (HA) as skin penetration enhancer to mometasone furoate (MF) to enhance its skin absorption, and so decrease the dose and side effects in different types of topical formulations including absorption ointment base, oil in water emulsion base and water in oil emulsion base in addition to alcoholic gel base. MF was introduced into the bases with and without the addition of 0.1% HA. The prepared formulations were evaluated for physical appearance, rheological behavior, drug release through a standard cellophane membrane and antiinflammatory effects in carrageenan-induced oedema in male albino rats. Results showed that all formulations showed good and acceptable physical properties. The in-vitro release rate of each base and its corresponding one, with 0.1% HA, showed no statistical differences.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Usama Farghaly Aly. 2014. \u201cReducing Topical Mometasone Furoate Doses by Applying Hyaluronic Acid as a Skin Penetration Enhancer\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B5): .

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GJMR Volume 14 Issue B5
Pg. 13- 23

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti-inflammatory dose hyaluronic acid mometasone furoate release rheology topical

Submission ReceivedDecember 11, 2013
Peer Review Double Blind
Handling Editor
Accepted January 1, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

October 25, 2014

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Article Matrices

Total Score: 103

Country: Egypt

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Khaled Aly Khaled, Usama Farghaly Aly, Doaa Amal Tawfik (PhD/Dr. count: 0)

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Publish Date: 2014 10, Sat

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Total Views: 4671

Total Downloads: 2408

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