Regulation of Specific Cell Clusters in TCR-T Cells Responding to Differential Expression of Tumor PD-L1

Renpeng Ding; Shang Liu; Huanyi Chen; Bin Kang; Radoje Drmanac; Ying Gu

Regulation of Specific Cell Clusters in TCR-T Cells Responding to Differential Expression of Tumor PD-L1

Renpeng Ding * §

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Shang Liu

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Huanyi Chen

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Bin Kang

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Ying Gu

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§ University of Chinese Academy of Sciences

Regulation of Specific Cell Clusters in TCR-T Cells Responding to Differential Expression of Tumor PD-L1

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Abstract

PD-L1 signaling is essential in regulating T cell function and keeping the balance of tumor microenvironment, but its role in modifying TCR-T cell cytotoxicity remains unknown. MART-1-specific TCR-T cells (TCR-T MART-1 ) were stimulated by MEL-526 tumor cells expressing different proportions of PD-L1 and used to perform cytotoxicity assays and single-cell RNA sequencing. Percentage changes of different specific cell clusters were analyzed. The percentage of cluster HLA-DR + CD38 + CD8 + was upregulated after antigen stimulation, and tumor PD-L1 modified TCR-T cell function through downregulating the percentages of HLA-DR + CD28 + CD8 + and HLA-DR + CD38 + CD8 + subsets which were higher in TCR-T MART-1 than in T null .

References

6 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Renpeng Ding, Shang Liu, Huanyi Chen, Bin Kang, Radoje Drmanac, Ying Gu. 2020. "Regulation of Specific Cell Clusters in TCR-T Cells Responding to Differential Expression of Tumor PD-L1". Global Journal of Medical Research, Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F8).

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GJMR Volume 20 Issue F8

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-F Classification NLMC Code: QU 300

Submission ReceivedDecember 10, 2019
Peer Review Double Blind
Handling Editor
Accepted January 2, 2020
Published January 15, 2020

Version of record

v1.2

Issue date

August 20, 2020

Language

English

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Article Matrices

Total Score: 178

Country: China

Subject: Global Journal of Medical Research

Authors: Renpeng Ding, Shang Liu, Huanyi Chen, Bin Kang, Radoje Drmanac, Ying Gu, Xuan Dong, Qianqian Gao (PhD/Dr. count: 0)

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