Reversible Antifertility Effect of Withaferin

Reversible Antifertility Effect of Withaferin

Sonal Dobhal

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Dr. Ashish Ranjan Singh

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Dr. Maheep Kumar

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University of Rajasthan

Reversible Antifertility Effect of Withaferin

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Abstract

Background: Currently world population crosses the 7.30 billion and increasing continuously day by day. There is a great need to support an individuals in family-planning since increasing growth rate of world’s population caused negative impact on sustainable, economic growth and increased poverty especially in developing countries. However, there is still no method available in the field of male contraception that satisfies the essential criteria of safety, efficacy, economy and complete reversibility. Clearly, there is a need for development of reversible contraceptive from natural resources. Therefore, we have performed the present study to examine the effect of Withaferin-A on the sexual hormone levels and to consider the effect of alkaloid of Withania somnifera on changes of glucose, cholesterol and triglyceride serum levels in male rats and can prevent the fertility of male albino rat by evaluating some andrological parameters such as sperm motility, sperm counts, rate of fertility and morphology which are some of the indices that determine the ability of a male to produce viable spermatozoa.

References

81 Cites in Article

Reference Format

M Abercrombie (1946). Estimation of nuclear population from microtome sections.
M Akbarsha,S Vijendrakumar,B Kadalmani,R Girija,A Faridha (2001). Curative property of Withania somnifera Dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat.
M Akbarsha,A Stanley,H Averal (1995). Effect of Vincristine on Leydig cell and accessory reproductive organs.
Muhaned Al-Hindawi,Saadia Al-Khafaji,May Abdul-Nabi (1992). Anti-granuloma activity of Iraqi Withania somnifera.
A Almenara,G Escalante,E Gazzo,G Gonzales (2000). Transillumination to evaluate spermatogenesis: effect of testosterone enanthate in adult male rats.
John Amory (2016). Male contraception.
B Anawalt,J Amory (2001). Male hormonal contraception.
B Andallu,B Radhika (2000). Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.
M Azmeera,A Elumalai,M Eswaraiah,N Mathangi (2012). Anupdated review on anti-fertility plants-2012.
V Bajaj,R Gupta (2012). Fertility suppression in male albino rats by administration of methanolic extract of Opuntiadillenii.
G Bariya (2005). Alkaloid concentration in different part of the growing crop of Ashwagandha (Withaniasomnifera) at different growth intervals.
L Beckman,S Harvey (1996). Factors Affecting the Consistent Use of Barrier Methods of Contraception.
J Bullock,J Boyle,M Wang (1995). Physiology.
K Chitra,C Latchoumycandane,P Mathur (1999). Chronic effect of endosulfan on the testicular functions of rat.
Abhishek Kumar,Nandita Moitra,K Jayachandran (2006). ASSESSMENT OF WATER QUALITY OF RIVER YAMUNA USING POLLUTION INDICES.
Ian Craft,Valerie Bennett,Natasha Nicholson (1993). Fertilising ability of testicular spermatozoa.
R Dolfman,E Forchielli,M Gut (1963). Androgen biosynthesis and related studies.
D Foreman (1973). A modification of the Roe procedure for determination of fructose in tissues with increase specificity.
M Ganzera,M Choudhary,I Khan (2003). Quantitative HPLC analysis of withanolides in Withania somnifera.
G Gupta,M Rajalakshmi,M Prasad,N Moudgal (1974). Alteration of epididymal function and its relation to maturation of spermatozoa.
M Gupta,U Mazumdar (1996). Antisteroidogenic effect of the seed extract of Nelumbonucifera in the testis and ovary of rat.
S Gupta (1978). Individual Towns and Regions - Prajnananda Banerjee, Calcutta and its Hinterland 1833–1900. Calcutta: Progressive Publishers, 1975. vi + 240 pp. Five appendices. Bibliography. Rs 30. - Maheshwar Dayal, Rediscovering Delhi: The Story of Shahjahanabad. New Delhi: S. Chand and Co., 1975. xvi + 237 pp. Bibliography. Rs 50..
Lee Grota,Kristen Eik-Nes (1967). PLASMA PROGESTERONE CONCENTRATIONS DURING PREGNANCY AND LACTATION IN THE RAT.
A Hazarika,H Sharma (2007). Effects of crude root extract of Polygonumhydropiper on estrous cycle and induction of reversible sterility in female albino rat.
Sachin Jain,Ankit Jain,Pritesh Paliwal,Shailendra Solanki (2012). Antifertility effect of chronically administered Tabernaemontana divaricata leaf extract on male rats.
Kuladip Jana,Subarna Jana,Prabhat Samanta (2006). Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action.
J Jensen (2002). Male contraception.
Roy Jones (1977). EFFECTS OF TESTOSTERONE, TESTOSTERONE METABOLITES AND ANTI-ANDROGENS ON THE FUNCTION OF THE MALE ACCESSORY GLANDS IN THE RABBIT AND RAT.
J Joshi,K Virkar,P Devi (1977). Effect of an Ayurvedic preparation on peripheral parameters of the menstrual cycle.
J Kachhawa,R Gupta,K Sharma (2012). SCREENING OF ISOLATED FRACTIONS OF DENDROPHTHOE FALCATA METHANOL STEM EXTRACT FOR ITS EFFECTS ON REPRODUCTIVE FUNCTIONS OF MALE RATS.
Ravi Khajuria,Krishan Suri,Rajinder Gupta,Naresh Satti,Musarat Amina,Om Suri,Ghulam Qazi (2004). Separation, identification, and quantification of selected withanolides in plant extracts of <i>Withania somnifera</i> by HPLC‐UV(DAD) – Positive ion electrospray ionisation–mass spectrometry.
S Kulshreshtha,R Mathur (1990). Effect of steroidal fraction of seed of Abrusprecatorius Linn. on rat testis.
Dinesh Kumar,Ajay Kumar,Om Prakash (2012). Potential antifertility agents from plants: A comprehensive review.
O Lowry,N Rosenbrough,A Far,R Randall (1951). Protein measurements with the folin phenol reagents.
Leda Lucinda,Camila Rocha,Maycon Reboredo,Vinícius Faria,Rita Sá (2011). Assessment of sperm production and reproductive organs of Wistar rats to long-term exposure of Caesalpinia ferrea.
T Mann (1964). Fructose polyols and organic acid. In: Biochemistry of semen and of the male reproductive tract.
T Mann (1964). The biochemistry of semen and the male reproductive tract McTheun.
M Melis (1995). Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects.
L Mishra,B Singh,S Dagenais (2000). Scientific Basis for the Therapeutic Use of Withaniasomnifera (Ashwagandha): A Review.
L Mishra,B Singh,S Dagenais (2000). Positive Inotropic Activity: Withaniasomnifera (Ashwagandha): a review.
Laxminarain Misra,Priyanka Mishra,Archana Pandey,Rajender Sangwan,Neelam Sangwan,Rakesh Tuli (2008). Withanolides from Withania somnifera roots.
Tatiana Montanari,João De Carvalho,Heidi Dolder (1998). Antispermatogenic effect of Achillea millefolium L. in mice.
P Moore,N Adler,S Kegeles (1996). Adolescents and the Contraceptive Pill: The Impact of Beliefs on Intentions and Use.
H Morse,D Leach,M Rowley,C Heller (1973). Effect of cyprotesone acetate on sperm concentration, seminal fluid volume, testicular cytology and levels of plasma and urinary ICSH, FSH and testosterone in normal men.
N Moudgal,G Murthy,K Prasanna Kumar,F Martin,R Suresh,R Medhamurthy,S Patil,S Sehgal,B Saxena (1997). Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: results of a pilot study.
N Moudgal,A Rao (1984). No. 46485 United Nations (United Nations fund for population activities) and Nepal.
I Nair,D Bhiwgade (1990). Effect of gossypol on pituitary reproductive axis: Ultrastructural and biochemical studies.
K Narayana,V Souza,A Sanyal,K Rao (2000). 5-Fluorouracil (5-FU) induces the formation of giant cell and slouging of seminiferous epithelium in rat testes.
E Nieschlag,H Behre,U Englemann,U Schwarzen (2000). Andrology.
V Njar,T Alao,J Okogun,Y Raji,A Bolarinwa,E Nduka (1995). Antifertility activity of Quasiaamara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.
Miwa Okamura,Takao Watanabe,Yoko Kashida,Noboru Machida,Kunitoshi Mitsumori (2004). Possible Mechanisms Underlying the Testicular Toxicity of Oxfendazole in Rats.
Anitha Pankajakshy,Indira Madambath (2009). Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol.
C Paulsen (1978). Male contraceptive development: re-examination of testosterone enanthate as an effective single entity agent.
L Potter (1996). How effective are contraceptives? The determination and measurement of pregnancy rates.
S Qian,Y Xu,Z Wei (1995). Recent progress in research on Tripterygium: A male antifertility plant.
Joseph Roe,Carl Kuether (1943). THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACID.
M Rajalakshmi,M Prasad (1977). Recent advances in the control of male reproductive functions.
M Rao (1988). Antifértility effects of alcoholic seed extract of Abrus precatorius Linn, in male albino rats.
V Rao,P Dasaradhan,K Krishanaiah (1979). Antifertility effect of some indigenous plants.
G Roja,M Heble,A Sipahimalani (2006). Tissue cultures of <i>Withania somnifera</i>: Morphogenesis and withanolide synthesis.
B Sarvamangala,K Krishnan,S Jayaraman,A Sheth (1983). Effect of Chronic Administration of Inhibin and Testosterone on Spermatogenesis in Adult Male Rats.
Paul Saxena,P (1991). Involvement of diatary glucose in adrenal steroidal regulation by spermatogenic and steroidogenic activity in preputertd rat testes.
Pallav Sengupta,Ashok Agarwal,Maria Pogrebetskaya,Shubhadeep Roychoudhury,Damayanthi Durairajanayagam,Ralf Henkel (2018). Role of Withania somnifera (Ashwagandha) in the management of male infertility.
Sunil Shah,D Jhade (2018). Evaluation of antifertility potential of Piper betle (Petiole) on female wistar rats “rising approaches of herbal contraception’’.
A Sharada,F Solomon,Pathirisseri Devi,Nayanabhirama Udupa,K Srinivasan (1996). Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo.
D Soejarto,A Bingel,M Slaytor,N Farnsworth (1978). Fertility regulating agents from plants.
J Speidel (2000). Population, Consumption, and Human Health.
S Sree,M Priya,C Naidu (2008). In vitro micropropagation studies from axillary bud explants of Withaniasomnifera Dual an important antitumor medicinal plants BTP -13.
A Stanley,H Averal,M Akbarsha (1993). Reproductive toxicity of vincristine in male rats.
Kalyan Sundaram,Narender Kumar (2000). 7α‐Methyl‐19‐nortestosterone (MENT): the optimal androgen for male contraception and replacement therapy.
R Swerdloff,C Bagatell,C Wang,B Anawalt,N Berman,B Steiner,W J Bremner (1998). Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) in maintained by TE alone.
Jennifer Tuxhorn,Gustavo Ayala,David Rowley (2002). REACTIVE STROMA IN PROSTATE CANCER PROGRESSION.
Martin Brockerhoff,United Nations (1998). World Urbanization Prospects: The 1996 Revision.
K Vogelsong (2005). Male contraception. World bank special programe of research development and research training in human reproduction.
Z Wang,Z Gu,L Cao,Y Xu,G You,B Mao,S Qian (1999). Effects of tripchlorolide on the epididymides and testes of rats.
L Warren (1959). Thethioburbituric acid assay of sialic acid.
E Williamson,D Okpako,F Evans (1996). Pharmacological methods in phyto-therapyresearch, volume I: selection preparation and pharmacological evaluation of plant material.
Who (1983). A prospective multicentre trial of the ovulation method of natural family planning. III. Characteristics of the menstrual cycle and of the fertile phase.
Who (1990). Contraceptive efficacy of testosterone-induced azoospermia in normal men.
Who (2000). Reproductive health research at WHO, a new beginning.
Xiufeng Wu,Ramamani Arumugam,Stephen Baker,Mary Lee (2004). Pubertal and Adult Leydig Cell Function in Mullerian Inhibiting Substance-Deficient Mice.

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The authors declare no conflict of interest.

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How to Cite This Article

Sonal Dobhal. 2020. \u201cReversible Antifertility Effect of Withaferin\u201d. Global Journal of Science Frontier Research - D: Agriculture & Veterinary GJSFR-D Volume 20 (GJSFR Volume 20 Issue D7).

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GJSFR Volume 20 Issue D7

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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-D Classification FOR Code: 039999

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Submission ReceivedJuly 10, 2020
Peer Review Double Blind
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Accepted August 9, 2020
Published August 23, 2020

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September 14, 2020

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