Review on Mycobacterial Metabolic Pathways as Drug Targets

1
Feyera Gemeda Dima
Feyera Gemeda Dima
2
Ebsa Bushura
Ebsa Bushura
1 Jimma University, Ethiopia

Send Message

To: Author

GJMR Volume 18 Issue C1

Article Fingerprint

ReserarchID

46T34

Review on Mycobacterial Metabolic Pathways as Drug Targets Banner
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scots Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sundanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu

Mycobacterium is acid fast genus of bacteria that include many pathogenic and non pathogenic species. Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease. The emergence of antibiotic resistance strains has raised the need towards the development of new antibiotics or drug molecules which can kill or suppress the growth of pathogenic Mycobacterium species. The increasing emergence of drug-resistant tuberculosis along with the HIV pandemic (human) threatens disease control and highlights both the need to understand how our current drugs work and the need to develop new and more effective drugs. Novel efforts in developing drugs that target the intracellular metabolism of M. tuberculosis often focus on metabolic pathways that are specific to mycobacterium. Potential drug targets were also identified from pathways related to lipid metabolism, carbohydrate metabolism, amino acid metabolism, energy metabolism, vitamin and cofactor biosynthetic pathways and nucleotide metabolism. Approximately one-fourth of the Mycobacterium tuberculosis genome contains genes that encode proteins directly involved in its metabolism. This review provides a brief historical account of tuberculosis drugs, metabolic pathways, examines the problem of current chemotherapy, discusses the targets of current tuberculosis drugs with focuses on some metabolic pathways. The identification of drug target form that unique metabolism of mycobacterium is crutial to to develop new drug for persistent and latent infection of tuberculosis.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Feyera Gemeda Dima. 2018. \u201cReview on Mycobacterial Metabolic Pathways as Drug Targets\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 18 (GJMR Volume 18 Issue C1): .

Download Citation

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-C Classification: NLMC Code: QW 125.5.M9
Version of record

v1.2

Issue date

July 30, 2018

Language

English

Experiance in AR

The methods for personal identification and authentication are no exception.

Read in 3D

The methods for personal identification and authentication are no exception.

Article Matrices
Total Views: 2881
Total Downloads: 1501
2026 Trends
Research Identity (RIN)
Related Research

Published Article

Mycobacterium is acid fast genus of bacteria that include many pathogenic and non pathogenic species. Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease. The emergence of antibiotic resistance strains has raised the need towards the development of new antibiotics or drug molecules which can kill or suppress the growth of pathogenic Mycobacterium species. The increasing emergence of drug-resistant tuberculosis along with the HIV pandemic (human) threatens disease control and highlights both the need to understand how our current drugs work and the need to develop new and more effective drugs. Novel efforts in developing drugs that target the intracellular metabolism of M. tuberculosis often focus on metabolic pathways that are specific to mycobacterium. Potential drug targets were also identified from pathways related to lipid metabolism, carbohydrate metabolism, amino acid metabolism, energy metabolism, vitamin and cofactor biosynthetic pathways and nucleotide metabolism. Approximately one-fourth of the Mycobacterium tuberculosis genome contains genes that encode proteins directly involved in its metabolism. This review provides a brief historical account of tuberculosis drugs, metabolic pathways, examines the problem of current chemotherapy, discusses the targets of current tuberculosis drugs with focuses on some metabolic pathways. The identification of drug target form that unique metabolism of mycobacterium is crutial to to develop new drug for persistent and latent infection of tuberculosis.

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]
×

This Page is Under Development

We are currently updating this article page for a better experience.

Request Access

Please fill out the form below to request access to this research paper. Your request will be reviewed by the editorial or author team.
X

Quote and Order Details

Contact Person

Invoice Address

Notes or Comments

This is the heading

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

High-quality academic research articles on global topics and journals.

Review on Mycobacterial Metabolic Pathways as Drug Targets

Ebsa Bushura
Ebsa Bushura
Feyera Gemeda Dima
Feyera Gemeda Dima Jimma University, Ethiopia

Research Journals