Rickettsial Infections: A Clinician’s Diagnostic Dilemma

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Sriranjani Iyer
Sriranjani Iyer
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Dr. Sriranjani Iyer
Dr. Sriranjani Iyer
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Dr. Harsh Rajeev Mehta
Dr. Harsh Rajeev Mehta
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Dr. Sarojini P. Jadhav
Dr. Sarojini P. Jadhav

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Rickettsial Infections: A Clinician’s Diagnostic Dilemma

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Abstract

Rickettsial diseases are arthropod borne zoonotic infections that are being increasingly recognized as one of the causes of pyrexia of unknown origin (PUO). These pathogens are gram-negative bacteria causing fever and rash, usually transmitted to humans by tick or flea bite. These infections must be differentiated from other febrile illnesses such as enteric fever, malaria, dengue, leptospirosis, and infectious mononucleosis. The common clinical presentation includes fever with chills and rigor, headache, vomiting, cough, conjunctival congestion and eschar. Presenting with varied and non-specific symptoms, ignorance, and low index of suspicion, they are often under-diagnosed due to the unavailability of the reliable diagnostic test. Weil-Felix test (WFT) is a non-specific heterophile tube agglutination test in which antibodies against rickettsiae are detected. If timely treatment with doxycycline is instituted the adverse consequences can be well averted.

References

10 Cites in Article
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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Sriranjani Iyer. 2020. \u201cRickettsial Infections: A Clinician’s Diagnostic Dilemma\u201d. Unknown Journal GJMR-I Volume 20 (GJMR Volume 20 Issue I1): .

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GJMR-I Classification: DDC Code: 595.2041 LCC Code: QL434.72
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v1.2

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May 21, 2020

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en
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Rickettsial diseases are arthropod borne zoonotic infections that are being increasingly recognized as one of the causes of pyrexia of unknown origin (PUO). These pathogens are gram-negative bacteria causing fever and rash, usually transmitted to humans by tick or flea bite. These infections must be differentiated from other febrile illnesses such as enteric fever, malaria, dengue, leptospirosis, and infectious mononucleosis. The common clinical presentation includes fever with chills and rigor, headache, vomiting, cough, conjunctival congestion and eschar. Presenting with varied and non-specific symptoms, ignorance, and low index of suspicion, they are often under-diagnosed due to the unavailability of the reliable diagnostic test. Weil-Felix test (WFT) is a non-specific heterophile tube agglutination test in which antibodies against rickettsiae are detected. If timely treatment with doxycycline is instituted the adverse consequences can be well averted.

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Rickettsial Infections: A Clinician’s Diagnostic Dilemma

Dr. Sriranjani Iyer
Dr. Sriranjani Iyer
Dr. Harsh Rajeev Mehta
Dr. Harsh Rajeev Mehta
Dr. Sarojini P. Jadhav
Dr. Sarojini P. Jadhav

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