Role of Ck-19, Hbme-1 and Galectin-3 in Prediction of Prognosis of Papillary Thyroid Carcinoma – An Experience from a Tertiary Care Centre
Introduction: Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of thyroid follicular epithelium. Its incidence has increased dramatically in past few decades reaching upto 80% of malignant thyroid tumors. Objectives: To assess the usefulness of the panel of immuno- histochemical markers – Cytokeratin 19 (CK19), Galectin 3 (GAL-3) and Hector Battifora mesothelial 1(HBME-1) in the prognostication of papillary thyroid carcinoma (PTC). Materials & methods: It was a single institution based, retrospective study done on 41 patients with biopsy proven papillary thyroid carcinoma at a tertiary centre of Eastern India. All the clinical and pathological data were reviewed. Patient’s age, sex, total tumor diameter, capsular invasion and lymph nodal metastasis were considered to be the prognostic parameters.
