Role of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection

1
R.M.Mukherjee
R.M.Mukherjee
2
Jyothi Arava
Jyothi Arava
3
P.Balkumar Reddy
P.Balkumar Reddy
4
P.N.Rao
P.N.Rao
5
R.Gupta
R.Gupta
6
D.N.Reddy
D.N.Reddy
1 Asian Health Care Foundation

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Background/Aim: Hepatitis B surface antigen(HBsAg) is routinely detected qualitatively in Hepatitis B Virus(HBV) infection where its persistence beyond 6 months defines chronic hepatitis B(CHB) infection. Hepatitis B e antigen (HBeAg) usually indicates active HBV replication and risk of transmission of infection. In spite of the emerging use of chemiluminescence based quantitative HBsAg assays for therapeutic monitoring of the patients, we measured HBsAg concentration by sandwich ELISA as a cost effective alternative to ascertain the role of HBsAg levels as surrogate marker of untreated HBeAg negative subjects having CHB infection.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

R.M.Mukherjee. 2014. \u201cRole of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection\u201d. Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 13 (GJSFR Volume 13 Issue G3): .

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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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v1.2

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January 23, 2014

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English

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Background/Aim: Hepatitis B surface antigen(HBsAg) is routinely detected qualitatively in Hepatitis B Virus(HBV) infection where its persistence beyond 6 months defines chronic hepatitis B(CHB) infection. Hepatitis B e antigen (HBeAg) usually indicates active HBV replication and risk of transmission of infection. In spite of the emerging use of chemiluminescence based quantitative HBsAg assays for therapeutic monitoring of the patients, we measured HBsAg concentration by sandwich ELISA as a cost effective alternative to ascertain the role of HBsAg levels as surrogate marker of untreated HBeAg negative subjects having CHB infection.

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Role of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection

R.M.Mukherjee
R.M.Mukherjee Asian Health Care Foundation
Jyothi Arava
Jyothi Arava
P.Balkumar Reddy
P.Balkumar Reddy
P.N.Rao
P.N.Rao
R.Gupta
R.Gupta
D.N.Reddy
D.N.Reddy

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