Roles of Cyclin Dependent Kinase and CDK-Activating Kinase in Cell cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization

1
Dr. Umar Saeed
Dr. Umar Saeed MS/ M-Phil (Applied Biosciences: Major Healthcare Biotechnology)
2
Nasir Jalal
Nasir Jalal
3
Muhammad Ashraf
Muhammad Ashraf
1 National University of Sciences and Technology (NUST), Islamabad Pakistan.

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Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding activity, phosphorylation through CDK activating kinase (CAK), Cdc25, Wee 1 kinase. Non-cyclin CDK activators include CDK5 activators, Viral Cyclins and RINGO/Speedy. Among all CDK activators, CAK carries prime importance. The time frame of activating phosphorylation varies across different model organisms. A literature search was performed via using Keywords: Cyclin-dependent kinases, CDK activating kinases, Interactions of CDK activating kinase, Association of CDK activating enzymes with cellular proteins, Cell cycle regulation via CDKs, Structure and Function of CDK activating kinases in Pubmed and Google scholar. The key findings on the basis of previous studies illustrated that the CDK3, CDK4 and CDK6 are associated with regulation of G1-S phase transition; CDK2 is involved in entrance to S phase and DNA replication; while CDK1 is vital for mitosis. The CDK activity is regulated via cyclin binding, cyclin-dependent kinase inhibitors CKIs, CDK phosphorylation at ATP-binding pocket for inhibition while for activation CDK phosphorylation occurs at T-loop conserved residue.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Dr. Umar Saeed. 1970. \u201cRoles of Cyclin Dependent Kinase and CDK-Activating Kinase in Cell cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization\u201d. Unknown Journal GJMR Volume 12 (GJMR Volume 12 Issue 11): .

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Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding activity, phosphorylation through CDK activating kinase (CAK), Cdc25, Wee 1 kinase. Non-cyclin CDK activators include CDK5 activators, Viral Cyclins and RINGO/Speedy. Among all CDK activators, CAK carries prime importance. The time frame of activating phosphorylation varies across different model organisms. A literature search was performed via using Keywords: Cyclin-dependent kinases, CDK activating kinases, Interactions of CDK activating kinase, Association of CDK activating enzymes with cellular proteins, Cell cycle regulation via CDKs, Structure and Function of CDK activating kinases in Pubmed and Google scholar. The key findings on the basis of previous studies illustrated that the CDK3, CDK4 and CDK6 are associated with regulation of G1-S phase transition; CDK2 is involved in entrance to S phase and DNA replication; while CDK1 is vital for mitosis. The CDK activity is regulated via cyclin binding, cyclin-dependent kinase inhibitors CKIs, CDK phosphorylation at ATP-binding pocket for inhibition while for activation CDK phosphorylation occurs at T-loop conserved residue.

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Roles of Cyclin Dependent Kinase and CDK-Activating Kinase in Cell cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization

Dr. Umar Saeed
Dr. Umar Saeed National University of Sciences and Technology (NUST), Islamabad Pakistan.
Nasir Jalal
Nasir Jalal
Muhammad Ashraf
Muhammad Ashraf

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