Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study

Dr. Safila Naveed

Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study

Dr. Safila Naveed * §

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Faculty of Pharmacy Jinnah University for women Karachi

Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study

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Abstract

A rapid, simple, accurate, and economical least time consuming rosuvastatin spectrophotometric method has been developed for the assay of atorvastatin and then compare assay of brand available in Karachi,Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 244nm wavelength of atorvastatin using methanol as solvent. A sample of drug was dissolved in methanol to produce a solution containing atorvastatin. Similarly, a sample of ground tablets of different brand were extracted with methanol and diluted with the same methanol. The absorbance of sample preparation was measured at 244 nm against the solvent blank and the assay was determined by comparing with the absorbance of available brand. The method can be applied for the routine QC quantitation of atorvastatin in tablet formulation and active.

References

10 Cites in Article

Reference Format

Jonathan Tobert (2003). Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.
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Najma Sultana,M Arayne,Safila Naveed (2010). Simultaneous Determination of Captopril and Statins in API, Pharmaceutical Formulations and in Human Serum by RP‐HPLC.
Najma Sultana,M Arayne,Shabana Shah,Nighat Shafi,Safila Naveed (2010). Simultaneous Determination of Prazosin, Atorvastatin, Rosuvastatin and Simvastatin in API, Dosage Formulations and Human Serum by RP‐HPLC.
N Sultana,M Arayne,Safila Naveed (2011). Validated Method for the Simultaneous Determination of Lisinopril, Pravastatin, Atorvastatin and Rosuvastatin in API, Formulations and Human Serum by RP-HPLC.
Najma Sultana,M Arayne,Safila Naveed (2011). SIMULTANEOUS DETERMINATION OF ENALAPRIL AND STATIN'S IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC.
M Arayne,N Sultana,Arman,Tabassum Saeeda,Nadir Ali,Safila Naveed (2012). Simultaneous LC Determination of Rosuvastatin, Lisinopril, Captopril, and Enalapril in API, Pharmaceutical Dosage Formulations, and Human Serum Medicinal.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Naveed, Dr. Naveed. 2014. "Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study". Global Journal of Medical Research, Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B2).

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GJMR Volume 14 Issue B2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

assay atorvastatin uv pectrophotometry

Classification

GJMR-B Classification NLMC Code: QV 55

WB 330

Submission ReceivedDecember 6, 2013
Peer Review Double Blind
Handling Editor
Accepted January 5, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

June 3, 2014

Language

English

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Article Matrices

Total Score: 146

Country: Pakistan

Subject: Global Journal of Medical Research

Authors: Dr. Safila Naveed (PhD/Dr. count: 1)

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Publish Date: 2014 01, Wed

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