Spectrophotometric Determination of Sodium Salicylate in Pharmaceutical Preparations by Coupling with Diazotized Paraamino Benzoic Acid

Spectrophotometric Determination of Sodium Salicylate in Pharmaceutical Preparations by Coupling with Diazotized Paraamino Benzoic Acid

Mohauman Mohammad Al-Rufaie

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University of Kufa

Spectrophotometric Determination of Sodium Salicylate in Pharmaceutical Preparations by Coupling with Diazotized Paraamino Benzoic Acid

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Abstract

A rapid, sensitive and simple spectrophotometric procedure for the assay of the smaller amounts measures from sodium salicylate at pharmaceutical preparations (topical-solution) was examined. The procedure is focus on a diazotization and reaction coupling between sodium salicylate and diazotized para-amino benzoic acid in alkaline medium for the formation of an intensive bright yellow soluble water colour which was being stable, which gives highly absorption at 452nm. The law of Beer was Introduced on the range of concentration from(2-30) μg.ml -1 of sodium salicylate, the molar absorptivity and the sensitivity of Sandell index were 8.5013×10 3 l mol -1 cm -1 , 0.0188 μg/cm 2 subsequently, The procedure does not need to the control of temperature and the extraction by the solvent. The perfect circumstances for all colour increasing are portrayed and the examined procedure has been very good application on the assay of sodium salicylate at topical-solution preparations. The general excipients materials and additives did not affect the examined procedure.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Mohauman Mohammad Al-Rufaie. 2016. \u201cSpectrophotometric Determination of Sodium Salicylate in Pharmaceutical Preparations by Coupling with Diazotized Paraamino Benzoic Acid\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 16 (GJSFR Volume 16 Issue B3).

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GJSFR Volume 16 Issue B3

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

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Classification

GJSFR-B Classification FOR Code: 030599

Submission ReceivedJuly 3, 2016
Peer Review Double Blind
Handling Editor
Accepted July 26, 2016
Published August 5, 2016

Version of record

v1.2

Issue date

October 12, 2016

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Article Matrices

Total Score: 101

Country: Iraq

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Mohauman Mohammad Al-Rufaie (PhD/Dr. count: 0)

View Count (all-time): 185

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Total Views: 3696

Total Downloads: 1873

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