Stem Cell Therapy in Multiple Myeloma

Roshna P P

Stem Cell Therapy in Multiple Myeloma

Roshna P P * §

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§ Government Medical College

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Abstract

Multiple myeloma is a haematogical malignancy caused by abnormality of plasma cells characterized by (a) hypercalcemia, (b) renal insufficiency or failure, (c)bone pain and abnormal bone radiographs, (d) anemia and (e) a monoclonal protein in urine or serum or both. It begins in the form known as monoclonal gammopathy of undetermined significance (MGUS) and progresses to asymptomatic myeloma and then lastly to symptomatic myeloma. The three main domains in the understanding of Pathophysiology are cytokines and cell signaling, bone Marrow Microenvironment and cell Cycle. Bifunctional alkylating agents like Melphalan and cyclophosphamide are considered as standard therapy for multiple myeloma. Patients who are chosen for stem cell transplantation can be treated with Lenalidomide, an immunomodulatory agent and an aminosustituted variant of Thalidomide. It is given along with dexamethas one. In stem cell therapy, the patients receive stem cells intravenously similar to the blood transfusion and this phase takes 1-5 hours. After entering the blood stream through a process called engraftment, the stem cell produce new WBCs, RBCs and platelets. The immune rejection of donor cells by the host immune system is a major drawback of transplantation. Stem cell therapy in multiple myeloma is very effective and should be opted as one among the best for both older patients and patients younger than 65 years.

References

19 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Roshna P P. 2018. "Stem Cell Therapy in Multiple Myeloma". Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 18 (GJMR Volume 18 Issue C1).

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GJMR Volume 18 Issue C1

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-C Classification NLMC Code: WH 540

Submission ReceivedDecember 14, 2017
Peer Review Double Blind
Handling Editor
Accepted January 2, 2018
Published January 15, 2018

Version of record

v1.2

Issue date

July 30, 2018

Language

English

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Article Matrices

Total Score: 142

Country: India

Subject: Global Journal of Medical Research

Authors: Roshna P P, Sreejith K (PhD/Dr. count: 0)

View Count (all-time): 366

Total Views (Real + Logic): 667

Total Downloads (simulated): 30

Publish Date: 2018 01, Mon

Monthly Totals (Real + Logic):

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Total Views: 667

Total Downloads: 30

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