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ReserarchID
VA035
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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In this study, the antidiabetic activity of purified fractions of the endophytic fungus Penicillium brevicaule alba-CC200 isolated from the plant Celosia cristata was investigated. Antidiabetic activity was evaluated by inhibition of α-amylase enzyme. The secondary metabolites of P. brevicaule alba-CC200 were partially purified by column chromatography and obtained fraction II inhibited α-amylase by 91.2%. High inhibitory activity was observed in fraction II and was determined to be cardiac glycosides and terpenoids by thin layer chromatography (TLC) and qualitative analysis. This requires a more precise study of the purified fractions using high-precision chromatographic methods.
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