Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of  the Endophytic Fungus Penicillium Brevicaule Alba-CC200

Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200

Mukhammedov Iqbol Iqbol * §

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Gulyamova Tashkhan

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Ruzieva Dilaram

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Nasmetova Saodat

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Turdimuhammadova Sarvinoz

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§ Andijan State University

Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200

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Abstract

In this study, the antidiabetic activity of purified fractions of the endophytic fungus Penicillium brevicaule alba-CC200 isolated from the plant Celosia cristata was investigated. Antidiabetic activity was evaluated by inhibition of α-amylase enzyme. The secondary metabolites of P. brevicaule alba-CC200 were partially purified by column chromatography and obtained fraction II inhibited α-amylase by 91.2%. High inhibitory activity was observed in fraction II and was determined to be cardiac glycosides and terpenoids by thin layer chromatography (TLC) and qualitative analysis. This requires a more precise study of the purified fractions using high-precision chromatographic methods.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Mukhammedov Iqbol, Gulyamova Tashkhan, Ruzieva Dilaram, Nasmetova Saodat, Turdimuhammadova Sarvinoz. 2026. "Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200". Global Journal of Medical Research, Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 23 (GJMR Volume 23 Issue C2).

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GJMR Volume 23 Issue C2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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Classification

GJMR-C Classification DDC Code: 579.173 LCC Code: QR351

Submission ReceivedFebruary 9, 2023
Peer Review Double Blind
Handling Editor
Accepted February 16, 2023
Published June 6, 2023

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v1.2

Issue date

June 6, 2023

Language

English

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