Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

Somayeh Afsah Vakili

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Arash Parvizi

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Rajiv Gandhi University of Health Sciences

Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

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Abstract

In consideration of the synthetic chemicals chemotherapy has induced obnoxious hazards, there is a ubiquitous tend towards the natural resources, which are remedially potent and affordable for the poor people. Development of phenolic compounds or extracts has become a major area medical research due to their cancer preventive effects through induction apoptosis and prevention of oxidative stress associated cancer. The present scrutiny was designed to investigate the synergic anticancer effect of Punica grantum L and Ziziphus maritiana. The ethanol extract of combination of both plants were found to be the most effective in BSL and trypan blue assay, also stimulated caspase-8 and-9 protease by fold increase in Ac-IETD-pNA. The expression of P 53 in cytoplasm and nuclei and the increase of TdT in the nuclei of carcinoma cells in mice treated while Bcl 2 expression was declined. Consequently, the synergic anticancer activity of ethanol extract of combination of both plants was proved.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Somayeh Afsah Vakili. 2017. \u201cSynergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 16 (GJMR Volume 16 Issue B4).

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GJMR Volume 16 Issue B4

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QZ 20.5

Submission ReceivedDecember 14, 2015
Peer Review Double Blind
Handling Editor
Accepted December 31, 2015
Published January 15, 2016

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February 2, 2017

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Article Matrices

Total Score: 102

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Somayeh Afsah Vakili, Arash Parvizi (PhD/Dr. count: 0)

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