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Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

§ Visveswarapura Institute of Pharmaceutical Sciences

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Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

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Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice Banner

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Abstract

In consideration of the synthetic chemicals chemotherapy has induced obnoxious hazards, there is a ubiquitous tend towards the natural resources, which are remedially potent and affordable for the poor people. Development of phenolic compounds or extracts has become a major area medical research due to their cancer preventive effects through induction apoptosis and prevention of oxidative stress associated cancer. The present scrutiny was designed to investigate the synergic anticancer effect of Punica grantum L and Ziziphus maritiana. The ethanol extract of combination of both plants were found to be the most effective in BSL and trypan blue assay, also stimulated caspase-8 and-9 protease by fold increase in Ac-IETD-pNA. The expression of P 53 in cytoplasm and nuclei and the increase of TdT in the nuclei of carcinoma cells in mice treated while Bcl 2 expression was declined. Consequently, the synergic anticancer activity of ethanol extract of combination of both plants was proved.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Somayeh Afsah Vakili, Arash Parvizi. 2017. "Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice". Global Journal of Medical Research GJMR-B Volume 16 (GJMR Volume 16 Issue 37 (B4)).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-B Classification NLMC Code: QZ 20.5
Version of record
v1.2

Issue date
November 4, 2016

Language
English
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Synergic Anticancer Activity of Different Extracts of Ziziphusa Mauritiana and Punica Grantum L on the Inhibition of Hela Cell Proliferation and Tumor Growth in EAC Bearing Mice

Somayeh Vakili
Somayeh Vakili Visveswarapura Institute of Pharmaceutical Sciences
Arash Parvizi
Arash Parvizi <p>Visveswarapura Institute of Pharmaceutical Sciences</p>