Synthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases

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Hamid Hussein Eissa
Hamid Hussein Eissa
1 Applied College Sciences, University of Hajah, Yemen.

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In this work we focused on the synthesis of two new macrocyclic Schiff bases: (III), ( IV), (VI) containing nitrogen -oxygen donor atoms were synthesized by condensation of intermediate compounds: 1,6-bis (2-formylphenel) hexane (I)and α,α’-bis (2-carboxyaldehyde phenoxy) xylene(II) with 4,4′-Diamino-diphenylmethane and 4-Aminophenyl sulfone. Also new open Schiff bases (V) which were prepared by condensation of benzylhydrazidewith 1, 6-bis (2-formylphenel) hexane (I). Identification of these macrocyclic Schiff bases: 1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl methane-5,12-di oxacyclo penta-icozane-1,15-diene(III), 1,16-di aza-3,4, 7, 10, 13,14-tri phenyl-17,25 -di phenyl methan-5,8-di oxacyclo penta-icozane-1,15-diene. (IV).1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl sulphide-5,12-di oxacyclo penta-icozane-1,15-diene(V), And N’,N’-(2,2′-(hexane-1,6-bis(oxy))bis(2,1-phenylene)) bis(methanylidene) dibenzhydra-zide. (VI).The Schiff bases were checked by different spectral technique (LC-MS, 1H-NMR, IR, elemental analyses). The new Schiff Bases were studied for antibacterial activities against (Bacillus subtilis and Staphylococcus aureus) are Gram positive and (Salmonella typhi and Escherichia coli) are Gram negative. The ligands were exhibited a variable activity of inhibition on the growth of the bacteria.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Hamid Hussein Eissa. 2014. \u201cSynthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 14 (GJSFR Volume 14 Issue B2): .

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GJSFR Volume 14 Issue B2
Pg. 39- 49
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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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May 28, 2014

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English

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In this work we focused on the synthesis of two new macrocyclic Schiff bases: (III), ( IV), (VI) containing nitrogen -oxygen donor atoms were synthesized by condensation of intermediate compounds: 1,6-bis (2-formylphenel) hexane (I)and α,α’-bis (2-carboxyaldehyde phenoxy) xylene(II) with 4,4′-Diamino-diphenylmethane and 4-Aminophenyl sulfone. Also new open Schiff bases (V) which were prepared by condensation of benzylhydrazidewith 1, 6-bis (2-formylphenel) hexane (I). Identification of these macrocyclic Schiff bases: 1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl methane-5,12-di oxacyclo penta-icozane-1,15-diene(III), 1,16-di aza-3,4, 7, 10, 13,14-tri phenyl-17,25 -di phenyl methan-5,8-di oxacyclo penta-icozane-1,15-diene. (IV).1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl sulphide-5,12-di oxacyclo penta-icozane-1,15-diene(V), And N’,N’-(2,2′-(hexane-1,6-bis(oxy))bis(2,1-phenylene)) bis(methanylidene) dibenzhydra-zide. (VI).The Schiff bases were checked by different spectral technique (LC-MS, 1H-NMR, IR, elemental analyses). The new Schiff Bases were studied for antibacterial activities against (Bacillus subtilis and Staphylococcus aureus) are Gram positive and (Salmonella typhi and Escherichia coli) are Gram negative. The ligands were exhibited a variable activity of inhibition on the growth of the bacteria.

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Synthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases

Hamid Hussein Eissa
Hamid Hussein Eissa Applied College Sciences, University of Hajah, Yemen.

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