Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents

1
Dr. B.M.Kalshetty
Dr. B.M.Kalshetty
2
Dr. Basavaraj M. Kalshetty
Dr. Basavaraj M. Kalshetty
3
Ramesh S. Gani
Ramesh S. Gani
4
M.B.Kalashetti
M.B.Kalashetti
1 Karnatak University DHARWAD

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Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents Banner
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The derivatives of Indole show biological activities including herbicidal. The newly synthesized compounds 1-phenylethyl,2-methyl,3-ethoxy carbonyl,5-methoxycarbonyl ,2methoxy Indole (Compound 2) were prepared by treating 1-phenyl,3-ethoxycarbonyl,5hydroxy,2-methyl Indole (Com-pound 1) successively with methyl bromo-acetate and refluxing with K2CO3 / KI in the presence of dry acetone. Newly synthesized compound 2 refluxed with hydrazine hydrate in alcoholic media forming 1-Phenylethyl,3-ethoxy carbonyl,2-methyl Indole,5yl oxy acetic acid hydrizide (Compound 3). This drug which on separately reacting with carbon disulphide, phenyl iso-thiocynide, acetylacetone, triethylorthoformate gave condensed bridge head heterocyclic’s such as 1-Phenyl ethyl,2-methyl,3-ethoxy cabonyl,5(5′-mercapto,1′-3′-4’oxadiazol,2′-yl )-methoxy Indole (Compound 4).

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Dr. B.M.Kalshetty. 2012. \u201cSynthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B7): .

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GJSFR Volume 12 Issue B7
Pg. 33- 44
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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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December 8, 2012

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English

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The derivatives of Indole show biological activities including herbicidal. The newly synthesized compounds 1-phenylethyl,2-methyl,3-ethoxy carbonyl,5-methoxycarbonyl ,2methoxy Indole (Compound 2) were prepared by treating 1-phenyl,3-ethoxycarbonyl,5hydroxy,2-methyl Indole (Com-pound 1) successively with methyl bromo-acetate and refluxing with K2CO3 / KI in the presence of dry acetone. Newly synthesized compound 2 refluxed with hydrazine hydrate in alcoholic media forming 1-Phenylethyl,3-ethoxy carbonyl,2-methyl Indole,5yl oxy acetic acid hydrizide (Compound 3). This drug which on separately reacting with carbon disulphide, phenyl iso-thiocynide, acetylacetone, triethylorthoformate gave condensed bridge head heterocyclic’s such as 1-Phenyl ethyl,2-methyl,3-ethoxy cabonyl,5(5′-mercapto,1′-3′-4’oxadiazol,2′-yl )-methoxy Indole (Compound 4).

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Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents

Dr. Basavaraj M. Kalshetty
Dr. Basavaraj M. Kalshetty
Ramesh S. Gani
Ramesh S. Gani
M.B.Kalashetti
M.B.Kalashetti

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