Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents

Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents

Dr. B.M.Kalshetty

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Dr. Basavaraj M. Kalshetty

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Ramesh S. Gani

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M.B.Kalashetti

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Karnatak University

Synthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents

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Abstract

The derivatives of Indole show biological activities including herbicidal. The newly synthesized compounds 1-phenylethyl,2-methyl,3-ethoxy carbonyl,5-methoxycarbonyl ,2methoxy Indole (Compound 2) were prepared by treating 1-phenyl,3-ethoxycarbonyl,5hydroxy,2-methyl Indole (Com-pound 1) successively with methyl bromo-acetate and refluxing with K2CO3 / KI in the presence of dry acetone. Newly synthesized compound 2 refluxed with hydrazine hydrate in alcoholic media forming 1-Phenylethyl,3-ethoxy carbonyl,2-methyl Indole,5yl oxy acetic acid hydrizide (Compound 3). This drug which on separately reacting with carbon disulphide, phenyl iso-thiocynide, acetylacetone, triethylorthoformate gave condensed bridge head heterocyclic’s such as 1-Phenyl ethyl,2-methyl,3-ethoxy cabonyl,5(5′-mercapto,1′-3′-4’oxadiazol,2′-yl )-methoxy Indole (Compound 4).

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Dr. B.M.Kalshetty. 2012. \u201cSynthesis and Biological Evaluation of Some New 1-Pheyl, 3-Ethoxycarbonyl, 5-Hydroxy Indole Derivatives as a Potential Antimicrobial Agents\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B7).

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GJSFR Volume 12 Issue B7

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

biological evaluation Indole derivatives potential and microbial agents

Submission ReceivedOctober 29, 2012
Peer Review Double Blind
Handling Editor
Accepted November 20, 2012
Published December 5, 2012

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v1.2

Issue date

December 8, 2012

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Article Matrices

Total Score: 108

Country: India

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Dr. Basavaraj M. Kalshetty, Ramesh S. Gani, M.B.Kalashetti (PhD/Dr. count: 1)

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