Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

Navneet Singh; R Agarwal; C Singh

Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

Navneet Singh * § ‡

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R C Agarwal §

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C P Singh ¶

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§ Department of Chemistry, Hindu College, Moradabad, 2...

‡ Department of Chemistry, Roorkee College of Engineer...

¶ Department of Chemistry, Sahu Jain College, Najibaba...

Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

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Abstract

Synthesis and evaluation of 3-(p methoxybenzylidene) hydrazinoacetylamino-2-methyl- 6- bromoquinazolin-4-(3 H)-one and 3-(p-N, N-dimethylbenzylidenylamino)hydrazine-acetylamino-2-methyi-quina-zolin-4 (3 H)-one for cardiovascular activity. Synthesis and evaluation of 3-(p methoxybenzylidene) hydrazinoacetylamino-2-methyl-6- bromoquinazolin-4-(3 H)-one and 3-(p-N, N-dimethylbenzylidenylamino)hydrazine-acetylamino-2- methyi-quina-zolin-4 (3 H)-one for cardiovascular activity methy-lmono substituted quinazolin- 4(3 H)-onyl)]-5’-(sub-stitu-tedphenyl)-tetrazolinum chloride (compounds 25-34).

References

17 Cites in Article

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1. M Helby,Abdel (2003). Unknown Title. Acta Pharma, 53, 127-138.
2. G Grover,S Kini (2006). Unknown Title. Eur. J. Med. Chem, 41, 256-262.
3. Rajan Giri,Hardik Thaker,Tony Giordano,Jill Williams,Donna Rogers,Vasudevan Sudersanam,Kamala Vasu (2009). Corrigendum to “Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents” [Eur J Med Chem 44 (2009) 2184–2189]. European Journal of Medicinal Chemistry, 44(11), 4783.
4. N Patel,V Patel (2007). Unknown Title. Iran. J. Pharm. Research, 6, 251-258.
5. D Raffa,G Daidone,B Maggio,D Schillaci,F Plescia (1999). Unknown Title. Pharmazie, 332, 317-320.
6. R Brogden,R Heel,T Speight,G Avery (1977). Prazosin. Drugs, 14(3), 163-197.
7. A Kumar,S Gurtu,J Sinha,K Bhargava,K Shanker (1985). Unknown Title. Eur. J. Med. Chem, 20(1), 95-96.
8. Shashikant Pattan,V Reddy,F Manvi,B Desai,A Bhat (2006). Synthesis of N‐3[4‐(4‐Chlorophenyl) thiazole‐2‐yl]‐2‐(aminomethyl)quinazoline‐4(3H)‐one and Their Derivatives for Antitubercular Activity. ChemInform, 37(47), 1771-1781.
9. Varsha Jatav,Pradeep Mishra,Sushil Kashaw,J Stables (2008). CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. European Journal of Medicinal Chemistry, 43(9), 1945-1954.
10. G Grover,S Kini (2006). Unknown Title. Eur. J. Med. Chem, 41, 256-262.
11. B Shah,J Bhatt,H Patel,N Undavia,P Trivedi,N Desai (1995). ChemInform Abstract: Synthesis of 2,3‐Disubstituted‐3,1‐quinazolin‐4(4H)‐ones as Potential Anticancer and Anti‐HIV Agents. ChemInform, 26(25), 201-208.
12. M Mohamed,M Kamel,E Kassem,A Nageh,S Nofal,F Marwa (2009). Unknown Title. Acta Poloniae Pharm. Drug Res, 66, 487-500.
13. R Arora,A Kapoor,N Gill,A Rana (2011). Unknown Title. IRJP, 2(12), 22-28.
14. Alvin Wheeler,W Oates (1910). THE BROMINATION OF ANTHRANILIC ACID. Journal of the American Chemical Society, 32(6), 770-773.
15. M Bogert,H Soil,H (1907). Unknown Title. J. Amer. Chem. Soc, 29, 517.
16. A Kumar,S Singh,A Saxena,K Shanker (1988). ChemInform Abstract: Synthesis of Quinazolinylpyrimidinediones and Their Antiinflammatory Activity. ChemInform, 19(42), 443.
17. Q Smith (1960). 1 Pharmacological Screening Tests. Progress in Medicinal Chemistry, 1, 1-33.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Navneet Singh, R C Agarwal, C P Singh. 2014. "Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue 30 (B7)).

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GJMR Volume 13 Issue 30 (B7)

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

antihypertensive activity cardiovascular formazan hydrazinoacetylamino quinazolinone derivatives

Classification

GJMR-B Classification NLMC Code: WC 168

Submission ReceivedDecember 8, 2012
Peer Review Double Blind
Handling Editor
Accepted December 31, 2012
Published January 15, 2013

Version of record

v1.2

Issue date

November 13, 2013

Language

English

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Article Matrices

Total Score: 103

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Navneet Singh, R C Agarwal, C P Singh (PhD/Dr. count: 0)

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