Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

Navneet Singh; R Agarwal; C Singh

Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

Navneet Singh §

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R C Agarwal ‡

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C P Singh ¶

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§ Roorkee College of Engineering, Roorkee, Uttarakhand...

‡ Department of Chemistry, Hindu College, Moradabad, 2...

¶ Department of Chemistry, Sahu Jain College, Najibaba...

Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity

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Abstract

3-(ethylacetylamino)-2-methylmono substituted quin- azolin-4(3H)-ones (compounds 1-2) were prepared by the reaction of ethylchloroacetate with 3-amino-2-methylmono- substituted quinazolin-4(3H)-one in dry acetone in the presence of anhydrous K2CO3. Compounds 1-2, on reaction with hydrazine hydrate (99-100%) in methanol gave 3- (hydrazinoacetylamino)-2-methylmono substitutedquinazolin-4 (3H) -ones (comp-ounds 3-4), which on reaction with different aromatic aldehyde gave 3- (substitutedarylidene) hydrazine- oacetylamino-2-methylmono substitutedquinazolin-4 (3H) – ones (compounds 5-14). These compounds (5-14) on reaction with substituted benzene diazonium chloride yielded 3- [(acetylamino-2-methylmono substitutedquinazol in-4(3H)- onyl)]-1’- (substitutedphenyl)-3’- (substitutedaryl)- formazans (compounds 15-24). These compounds on oxidation with H2O2, ferrous sulphate and H2SO4 showed intramolecular cycli- zation to give 2’ – (substitutedaryl) – 4’-[3-(acetylamino)-2- methyl-mono substituted quinazolin-4(3H)-onyl)]-5’-(sub-stitu- tedphenyl)-tetrazolinum chloride (compounds 25-34).

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Navneet Singh, R C Agarwal, C P Singh. 2014. "Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue 30 (B7)).

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GJMR Volume 13 Issue 30 (B7)

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

antihypertensive activity cardiovascular formazan hydrazi-noacetylamino quinazolinone derivatives

Classification

GJMR-B Classification NLMC Code: WC 168

Submission ReceivedDecember 8, 2012
Peer Review Double Blind
Handling Editor
Accepted December 31, 2012
Published November 13, 2013

Version of record

v1.2

Issue date

November 13, 2013

Language

English

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Article Matrices

Total Score: 103

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Navneet Singh, R C Agarwal, C P Singh (PhD/Dr. count: 0)

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