Synthesis Characterization and Antibacterial Activity of New Open and Macrocyclic Schiff Bases Ligands

Synthesis Characterization and Antibacterial Activity of New Open and Macrocyclic Schiff Bases Ligands

Hamid Hussein Eissa

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Synthesis Characterization and Antibacterial Activity of New Open and Macrocyclic Schiff Bases Ligands

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Abstract

In this work we focused on the synthesis of two new macrocyclic Schiff bases: (III) , (IV), (VI) containing nitrogen -oxygen donor atoms were synthesized by condensation of intermediate compounds: 1,6-bis (2-formylphenel) hexane (I)and α,α’-bis(2-carboxyaldehyde phenoxy) xylene(II) with 4,4′-Diamino-diphenylmethane and 4-Aminophenyl sulfone. Also new open Schiff bases (V) which were prepared by condensation of benzylhydrazidewith 1,6-bis (2-formylphenel) hexane (I). Identification of these macrocyclic Schiff bases: 1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl methane-5,12-di oxacyclo penta-icozane-1,15-diene(III), 1,16-di aza-3,4,7,10,13,14-tri phenyl-17,25 -di phenyl methan-5,8di oxacyclo penta-icozane-1,15-diene. (IV).1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl sulphide-5,12di oxacyclo penta-icozane-1,15-diene(V),and N’,N’-(2,2′-(hexane-1,6-bis(oxy)) bis(2,1-phenylene))bis (methanylidene) dibenzhydrazide. (VI).The Schiff bases were checked by different spectral technique (LC-MS, 1 H-NMR, IR, elemental analyses). The new Schiff Bases were studied for antibacterial activities against (Bacillus subtilis and Staphylococcus aureus) are Gram positive and (Salmonella typhi and Escherichia coli) are Gram negative. The ligands were exhibited a variable activity of inhibition on the growth of the bacteria.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Hamid Hussein Eissa. 2014. \u201cSynthesis Characterization and Antibacterial Activity of New Open and Macrocyclic Schiff Bases Ligands\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 14 (GJSFR Volume 14 Issue B3): .

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GJSFR Volume 14 Issue B3
Pg. 11- 21

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

antibacterial activity macrocyclic schiff bases open schiff bases spectral technique

Submission ReceivedApril 18, 2014
Peer Review Double Blind
Handling Editor
Accepted May 10, 2014
Published May 23, 2014

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June 21, 2014

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Article Matrices

Total Score: 101

Country: Yemen

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Hamid Hussein Eissa (PhD/Dr. count: 0)

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