Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring

1
Asmaa S. Salman
Asmaa S. Salman
2
Naema A. Mahmoud
Naema A. Mahmoud
3
Anhar Abdel-Aziem
Anhar Abdel-Aziem
4
Mona A. Mohamed
Mona A. Mohamed
5
Doaa M. Elsisi
Doaa M. Elsisi
1 Al-Azhar University

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Reaction 1H-indole-3-carboxaldhyde 1 with thiosemicarbazide derivatives to give thiosemicarbazone derivatives 2a,b. Cyclization of thiosemicarbazone 2a with HCl, Ac 2 O, phenacyl bromides and chloroacetic acid afforded the corresponding 1,2,4-triazole-3-thiol derivative 3, diacetyl derivative 4 and 1,3-thiazole derivative 5 and 1,3-thiazolidin-4-ones derivative 6 respectively. Compound 6 undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The structure of the newly synthesized compounds had been confirmed by elemental analysis and spectra data. The some newly synthesized compounds were evaluated for in vitro cytotoxic activity against three human cancer cell lines, including human liver cancer (HepG2), human colon cancer (HT-29) and human breast cancer (MCF-7) using MTT assay.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Asmaa S. Salman. 2016. \u201cSynthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 16 (GJSFR Volume 16 Issue B1): .

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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-B Classification: FOR Code: 030599
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v1.2

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March 1, 2016

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English

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Reaction 1H-indole-3-carboxaldhyde 1 with thiosemicarbazide derivatives to give thiosemicarbazone derivatives 2a,b. Cyclization of thiosemicarbazone 2a with HCl, Ac 2 O, phenacyl bromides and chloroacetic acid afforded the corresponding 1,2,4-triazole-3-thiol derivative 3, diacetyl derivative 4 and 1,3-thiazole derivative 5 and 1,3-thiazolidin-4-ones derivative 6 respectively. Compound 6 undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The structure of the newly synthesized compounds had been confirmed by elemental analysis and spectra data. The some newly synthesized compounds were evaluated for in vitro cytotoxic activity against three human cancer cell lines, including human liver cancer (HepG2), human colon cancer (HT-29) and human breast cancer (MCF-7) using MTT assay.

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Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring

Asmaa S. Salman
Asmaa S. Salman Al-Azhar University
Naema A. Mahmoud
Naema A. Mahmoud
Anhar Abdel-Aziem
Anhar Abdel-Aziem
Mona A. Mohamed
Mona A. Mohamed
Doaa M. Elsisi
Doaa M. Elsisi

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