Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring

Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring

Asmaa S. Salman

Contact

Naema A. Mahmoud

Contact

Anhar Abdel-Aziem

Contact

Mona A. Mohamed

Contact

Doaa M. Elsisi

Contact

Al-Azhar University

Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring

Article Fingerprint

ReserarchID

8YQ13

Synthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Reaction 1H-indole-3-carboxaldhyde 1 with thiosemicarbazide derivatives to give thiosemicarbazone derivatives 2a,b. Cyclization of thiosemicarbazone 2a with HCl, Ac 2 O, phenacyl bromides and chloroacetic acid afforded the corresponding 1,2,4-triazole-3-thiol derivative 3, diacetyl derivative 4 and 1,3-thiazole derivative 5 and 1,3-thiazolidin-4-ones derivative 6 respectively. Compound 6 undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The structure of the newly synthesized compounds had been confirmed by elemental analysis and spectra data. The some newly synthesized compounds were evaluated for in vitro cytotoxic activity against three human cancer cell lines, including human liver cancer (HepG2), human colon cancer (HT-29) and human breast cancer (MCF-7) using MTT assay.

References

24 Cites in Article

Reference Format

Dimitra Kovala-Demertzi,Paras Yadav,Mavroudis Demertzis,Mauro Coluccia (2000). Synthesis, crystal structure, spectral properties and cytotoxic activity of platinum(II) complexes of 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones.
S Singh,K Ashok,M Galal,C Amit (2015). Synthesis and antibacterial studies of some semicarbazones of some carbonyl compounds.
V Rao,M Rao,N Jain,J Panwar,A Kumar (2011). Silver triflate catalyzed synthesis of 3aminoalkylated indoles and evaluation of their antibacterial activities.
M Ismail,M Kamel,L Mohamed,S Faggal (2012). Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors.
R Chavan,H S ; More,A Bhosale (2010). Synthesis and evaluation of analgesic and antiinflammatory activities of a novel series of 3-(4, 5dihydropyrazolyl)-indoles.
Sunil Kumar,Samir Mehndiratta,Kunal Nepali,Manish Gupta,Surrinder Koul,Parduman Sharma,Ajit Saxena,Kanaya Dhar (2013). Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors.
Afshin Zarghi,A Tahghighi,Z Soleimani,B Daraie,G Dadrass,M Hedayati (2008). Design and Synthesis of Some 5-Substituted-2-(4-(azido or methylsulfonyl) phenyl)-1H-indole Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors.
Ö Güze,N ; Karali,A Salman (2008). Synthesis and antituberculosis activity of 5-methyl/ trifluoromethoxy-1H-indole-2,3-dione 3thiosemicarbazone derivatives.
Sadek Abdou,Salah El-Qusy,Sami Ghabrial,Mahmoud Haggag (2011). Reactions with Visnaginone: Synthesis, Cyclisation and Microbial Evaluation of Some Visnaginone Thiosemicarbazone Derivatives.
M Shih,Ling Wu,C (2005). Efficient syntheses of thiadiazoline and thiadiazole derivatives by the cyclization of 3-aryl-4-formylsydnone thiosemicarbazones with acetic anhydride and ferric chloride.
Adel Abdel‐rahman,Wael El‐sayed,El‐sayed Zaki,Asem Mohamed,Ahmed Fadda (2012). Synthesis and antimicrobial activity of substituted [(pyrazol‐4‐yl)methylene]hydrazono‐2,3‐dihydrothiazoles and their sugar derivatives.
O Ahmed,P Sharma,I Singhvi (2014). Synthesis and investigation of antimicrobial activity of novel Thiazolidinone derivatives.
K Prakasha,G Channe (2011). Synthesis of 5arylidine2-(3,4,5,trimethoxyphenyl)-3-(4-phenyl-thiazol-2-yl)thiazolidin-4-one derivatives as a novel class of antimicrobial agents.
M Rao,J Sreeramulu,L Ravindranath,G Naga-Rajareddy,K Hanumanthurayudu,G Nageswara Reddy,A Jayaraju1,P Madhusudhan Synthesis and biological screening of some Pyridine and Pyrrole derivatives of Pyrazolo.
Pyrazoles (2012). Unknown Title.
B Sailu,S Mahantia,A Satya Srinivas,B Balram,B Ram,B Taara,B Vasudh (2012). Synthesis and antibacterial activity of novel isoxazoline derivatives.
Nilesh Thumar,Manish Patel (2012). ChemInform Abstract: Synthesis, Characterization, and in vitro Microbial Evaluation of Some New 4H‐Chromene and Quinoline Derivatives of 1H‐Pyrazole..
E El-Rady (2008). A convenient and facile synthesis of new thiazole derivatives.
Samir Bondock,Wesam Khalifa,Ahmed Fadda (2007). Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde.
K El-Gaml (2015). Synthesis and antimicrobial evaluation of new polyfunctionally substituted heterocyclic compounds derived from 2-cyano-n-(3cyanoquinolin-2-yl)acetamide.
H Abdel-Aziz,A Gamal-Eldeen,N Hamdy,I Fakhr (2009). Immunomodulatory and a nticancer activity of some novel 2-substituted-6bromo-3-methylthiazolo[3,2-a]benzimidazole derivatives.
Tim Mosmann (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays.
A Monks,D Scudiero,P Skehan,R Shoemaker,K Paull,D Vistica,C Hose,J Langley,P Cronise,A Vaigro-Wolff,M Gray-Goodrich,H Campbell,J Mayo,M Boyd (1991). Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines.
N Marshall,C Goodwin,S Holt (1995). A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Asmaa S. Salman. 2016. \u201cSynthesis, Characterization and in Vitro Cytotoxic Evaluation of Some Novel Heterocyclic Compounds Bearing Indole Ring\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 16 (GJSFR Volume 16 Issue B1).

More Citation Formats

Select Citation Style:

Download Citation

GJSFR Volume 16 Issue B1

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

Not Found

Classification

GJSFR-B Classification FOR Code: 030599

Submission ReceivedOctober 9, 2015
Peer Review Double Blind
Handling Editor
Accepted November 2, 2015
Published November 14, 2015

Version of record

v1.2

Issue date

March 1, 2016

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 105

Country: Egypt

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Asmaa S. Salman, Naema A. Mahmoud, Anhar Abdel-Aziem, Mona A. Mohamed, Doaa M. Elsisi (PhD/Dr. count: 0)

View Count (all-time): 186

Total Views (Real + Logic): 3904

Total Downloads (simulated): 2097

Publish Date: 2016 03, Tue

Monthly Totals (Real + Logic):

Month 1: 35 views
Month 2: 60 views
Month 3: 65 views
Month 4: 25 views
Month 5: 30 views
Month 6: 35 views
Month 7: 18 views
Month 8: 40 views
Month 9: 48 views
Month 10: 41 views
Month 11: 34 views
Month 12: 25 views
Month 13: 11 views
Month 14: 32 views
Month 15: 16 views
Month 16: 33 views
Month 17: 30 views
Month 18: 25 views
Month 19: 43 views
Month 20: 45 views
Month 21: 28 views
Month 22: 25 views
Month 23: 21 views
Month 24: 22 views
Month 25: 39 views
Month 26: 48 views
Month 27: 32 views
Month 28: 39 views
Month 29: 49 views
Month 30: 36 views
Month 31: 23 views
Month 32: 17 views
Month 33: 37 views
Month 34: 17 views
Month 35: 43 views
Month 36: 20 views
Month 37: 36 views
Month 38: 25 views
Month 39: 28 views
Month 40: 35 views
Month 41: 29 views
Month 42: 31 views
Month 43: 12 views
Month 44: 24 views
Month 45: 38 views
Month 46: 27 views
Month 47: 31 views
Month 48: 28 views
Month 49: 21 views
Month 50: 14 views
Month 51: 19 views
Month 52: 18 views
Month 53: 28 views
Month 54: 44 views
Month 55: 28 views
Month 56: 25 views
Month 57: 31 views
Month 58: 28 views
Month 59: 30 views
Month 60: 34 views
Month 61: 19 views
Month 62: 28 views
Month 63: 26 views
Month 64: 38 views
Month 65: 31 views
Month 66: 25 views
Month 67: 45 views
Month 68: 22 views
Month 69: 21 views
Month 70: 25 views
Month 71: 34 views
Month 72: 36 views
Month 73: 21 views
Month 74: 41 views
Month 75: 34 views
Month 76: 35 views
Month 77: 26 views
Month 78: 32 views
Month 79: 21 views
Month 80: 35 views
Month 81: 25 views
Month 82: 30 views
Month 83: 34 views
Month 84: 27 views
Month 85: 26 views
Month 86: 35 views
Month 87: 27 views
Month 88: 23 views
Month 89: 31 views
Month 90: 16 views
Month 91: 29 views
Month 92: 23 views
Month 93: 41 views
Month 94: 22 views
Month 95: 37 views
Month 96: 18 views
Month 97: 23 views
Month 98: 20 views
Month 99: 25 views
Month 100: 22 views
Month 101: 27 views
Month 102: 28 views
Month 103: 24 views
Month 104: 36 views
Month 105: 29 views
Month 106: 50 views
Month 107: 38 views
Month 108: 29 views
Month 109: 23 views
Month 110: 40 views
Month 111: 18 views
Month 112: 40 views
Month 113: 40 views
Month 114: 41 views
Month 115: 39 views
Month 116: 28 views
Month 117: 36 views
Month 118: 34 views
Month 119: 37 views
Month 120: 40 views
Month 121: 37 views
Month 122: 45 views
Month 123: 34 views

Total Views: 3904

Total Downloads: 2097

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]