Synthesis of Biologically Important Pyrrole Derivatives in any 13C and 15N Isotope Enriched Form

Synthesis of Biologically Important Pyrrole Derivatives in any 13C and 15N Isotope Enriched Form

Dr. Prativa B. S. Dawadi

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Johan Lugtenburg

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Leiden University

Synthesis of Biologically Important Pyrrole Derivatives in any 13C and 15N Isotope Enriched Form

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Abstract

Recently the synthesis of [3-13 C]-, [4-13 C]-, and [11-13 C]-porphobilinogen, [ 15 N, 13 C4]-1H – pyrrole-2,3,5 -tricar -boxylic acid, [1-15 N]-3-cyano-4-methyl-1H-pyrrole and [2-13 C]-and [3-13 C]-cyano-4methyl-3-pyrrolin-2-one have been published. Incorporation of 13 C and 15 N in these systems at any position and combination of positions has become accessible. Also mild alkylations of active methylene compounds with α-halo carbonyl compounds open up many 3-pyrrolin-2-ones and pyrrole systems based on stable isotope building blocks that have been published. This gives the access to a whole new library of stable isotope enriched pyrroles in any stable isotope enriched form. This is also the case for biliverdin IXα which after enzymatic treatment has been converted into (2R)-phytochromobilin that reacts with its apoprotein to form intact active phytochrome.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

Dr. Prativa B. S. Dawadi. 2012. \u201cSynthesis of Biologically Important Pyrrole Derivatives in any 13C and 15N Isotope Enriched Form\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B2): .

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GJSFR Volume 12 Issue B2
Pg. 23- 36

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

[ 15N [1-15N]-3-Cyano-4-methyl-1H-pyrrole [3-13C][4-13C]-] -1H-pyrrole-2 13C4 3 5-tricarboxylic acid and biliverdi and [11-13C]-porphobilinogen

Submission ReceivedDecember 17, 2011
Peer Review Double Blind
Handling Editor
Accepted January 14, 2012
Published January 27, 2012

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v1.2

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February 29, 2012

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Article Matrices

Total Score: 127

Country: Netherlands

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Dr. Prativa B. S. Dawadi , Johan Lugtenburg (PhD/Dr. count: 1)

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