Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

Magbri A MD

Contact

Awad Magbri

Contact

Fiona Stevens

Contact

Pine (Partners in Nephrology and Endocrinology)

Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

Article Fingerprint

ReserarchID

KR91L

Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Design, setting, participants & measurements: One hundred and eight patients presented to the University College Hospital Galway, Ireland (UCHG) with upper gastro-intestinal symptoms were included in the study. There were 52 males with age range 18-82 years, mean age 49 years, and 56 females, age range 20-83 years, mean age 52 years. They were grouped according to the endoscopic findings into 4 groups (i) Duodenal Ulcer (DU), (ii) Gastric Ulcer (GU), (iii) Gastritis (GS), & (iv) Non-Ulcer Dyspepsia (NUD). Five milliliter of venous blood was taken in a sterile plain tube; the serum was separated and stored at -70 C0 for ELISA assay. Endoscopy was carried out and at least 4 biopsies were obtained, 2 from the antrum and 2 from the first part of the duodenum (duodenal bulb). One biopsy each from the antrum and duodenum was transferred immediately into a sterile container containing 2 mL of RPMI 1640. The other biopsy specimens one from the antrum and one from the duodenum were processed for histological examination. The serum IgG antibodies to H. pylori and local IgA and IgG were measured by an ELISA test.

References

42 Cites in Article

Reference Format

Melanie Weck,Lei Gao,Hermann Brenner (2009). Helicobacter pylori Infection and Chronic Atrophic Gastritis.
M Dixon,R Genta,J Yardley (1994). Classification and grading of gastritis. The update Sydney System. International Workshop on the Histopathology of Gastritis, Houston.
M Blaser,J Atherton (2004). Helicobacter pylori persistence: biology and disease.
A Ciociola,D Mcsorley,K Turner (1999). Helicobacter pylori infection rates in duodenal ulcer patients in the United States may be lower than previously estimated.
J Parsonnet,G Friedman,D Vandersteen (1994). Helicobacter pylori infection and gastric lymphoma.
Sicheng Wen,Steven Moss (2009). Helicobacter pylori virulence factors in gastric carcinogenesis.
Johannes Kusters,Arnoud Van Vliet,Ernst Kuipers (2006). Pathogenesis ofHelicobacter pyloriInfection.
X Sagaert,E Van Cutsem,De Hertogh,G (2010). Gastric MALT lymphoma: A model of chronic inflammation-induced tumor development.
M Blaser (1992). Hypotheses in the pathogenesis and natural history of Helicobacter pylori induced inflammation.
D Smooth,H Mobley,G Chippendale (1990). Helicobacter pylori urease activity is toxic to human gastric epithelial cells.
Hlt Mobley,L-T Hu,P Foxall (1991). Helicobacter pyloriUrease: Properties and Role in Pathogenesis.
D Newell (1991). Virulence Factors ofHelicobacter pylori.
T Cover,S Vaughn,P Cao,M Blaser (1992). Potentiation of Helicobacter pylori Vacuolating Toxin Activity by Nicotine and Other Weak Bases.
T Cover,C Dooley,M Blaser (1990). Characterization and human serology response to proteins in Helicobacter pylori broth culture supernatants with vacuolzing cytotoxin activity.
R Heatley (1991). Helicobacter pylori infection and inflammation.
T Karttunen,S Niemelä,J Lehtola (1991). Helicobacter pyloriin Dyspeptic Patients: Quantitative Association with Severity of Gastritis, Intragastric pH, and Serum Gastrin Concentration.
C Mollenkoph,H Steininger,G Weineck,M Meyer (1990). gastritis: immunohistochemical detection of specific and nonspecific immune response to Helicobacter pylori.
G Prieto,I Polanco,J Larrauri (1992). Helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations.
J Crabtree,T Shallcross,J Wyatt (1991). Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis.
E Stromberg,A Edebo,A Svennerholm (2003). Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infection duodenal ulcer patients.
Annika Hamlet,Ann Thoreson,Ola Nilsson,Ann Svennerholm,Lars Olbe (1999). Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers.
A Berstad,K Holbjorn,G Bukholm (2001). Complement activation directly induced by Helicobacter pylori.
H Mosbley (1996). Defining Helicobacter pylori as a pathogen: strain heterogeneity and virulence.
M Rohde,J Puls,R Buhrdorf (2003). A novel sheated surface organelle of Helicobacter pylori cag type IV secreation system.
Steffen Backert,Matthias Selbach (2008). Role of type IV secretion inHelicobacter pyloripathogenesis.
S Odenbreit,J Puls,B Sedlmaier (2000). translocation of Helicobacter pylori CagA into gastric epithelial cells by IV secretion.
Hideaki Higashi,Ryouhei Tsutsumi,Syuichi Muto,Toshiro Sugiyama,Takeshi Azuma,Masahiro Asaka,Masanori Hatakeyama (2002). SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein.
T Bertram,P Murray,D Morgan,G Jerdak,P Yang,S Czinn (1991). Gastritis Associated with Infection by Helicobacter pylori in Humans: Geographical Differences.
P Klein,D Graham,A Gaillour (1991). Water sources as risk factor for Helicobacter pylori infection in Peruvian children.
T Kosunen,K Seppäla,S Sarna,P Sipponen (1992). Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori.
A Maddocks (1990). Helicobacter pylori (formerly Campylobacter pyloridis/pylori) 1986-1989: a review..
Eaj Rauws,Gnj Tytgat (1989). Gist‐Brocades HFCS process.
J Dent,Cam Mcnullty,J Uff (1988). Campylobacter pylori urease: a new serological test.
C Goodwin,E Blincow,G Peterson,C Sanderson,W Cheng,B Marshall,J Warren,R Mcculloch (1987). Enzyme-Linked Immunosorbent Assay for Campylobacter pyloridis: Correlation with Presence of C. pyloridis in the Gastric Mucosa.
D Newell (1988). An Enzyme-Linked Immunosorbent Assay for the serodiagnosis of Campylobacter pylori-associated gastritis.
B Rathbone,J Wyatt,B Worsley (1985). Immune response to Campylobacter pyloridis.
H Steer,P Hawtin,D Newell (1987). An ELISA technique for the serodiagnosis of Campylobacter pyloridis infection in patients with gastric and benign duodenal ulceration.
N Talley,D Newell,J Ormand,H Carpenter,W Wilson,A Zinsmeister,G Perez-Perez,M Blaser (1991). Serodiagnosis of Helicobacter pylori: comparison of enzyme-linked immunosorbent assays.
D Newell,P Hawtin,A Stacey,M Macdougall,A Ruddle (1991). Estimation of prevalence of Helicobacter pylori infection in an asymptomatic elderly population comparing [14C] urea breath test and serology..
G Prieto,I Polanco,J Larrauri (1992). Helicobacter pylori infection in children: endoscopic, and histology correlations.
T Karttunen,S Niemelä,J Lehtola (1991). Helicobacter pyloriin Dyspeptic Patients: Quantitative Association with Severity of Gastritis, Intragastric pH, and Serum Gastrin Concentration.
K Alam,T Schubert,S Bologna,C Ma (1992). Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Magbri A MD. 2016. \u201cSystemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 16 (GJMR Volume 16 Issue F3).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 16 Issue F3

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-F Classification NLMC Code: WD 308

Submission ReceivedDecember 14, 2015
Peer Review Double Blind
Handling Editor
Accepted January 3, 2016
Published January 15, 2016

Version of record

v1.2

Issue date

July 4, 2016

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 132

Country: United States

Subject: Global Journal of Medical Research - F: Diseases

Authors: Awad Magbri, Fiona Stevens (PhD/Dr. count: 0)

View Count (all-time): 143

Total Views (Real + Logic): 3759

Total Downloads (simulated): 1817

Publish Date: 2016 07, Mon

Monthly Totals (Real + Logic):

Month 1: 50 views
Month 2: 51 views
Month 3: 35 views
Month 4: 36 views
Month 5: 26 views
Month 6: 37 views
Month 7: 43 views
Month 8: 49 views
Month 9: 49 views
Month 10: 49 views
Month 11: 33 views
Month 12: 30 views
Month 13: 28 views
Month 14: 27 views
Month 15: 29 views
Month 16: 28 views
Month 17: 23 views
Month 18: 25 views
Month 19: 46 views
Month 20: 20 views
Month 21: 18 views
Month 22: 16 views
Month 23: 36 views
Month 24: 22 views
Month 25: 36 views
Month 26: 19 views
Month 27: 29 views
Month 28: 41 views
Month 29: 13 views
Month 30: 31 views
Month 31: 29 views
Month 32: 15 views
Month 33: 46 views
Month 34: 29 views
Month 35: 38 views
Month 36: 37 views
Month 37: 18 views
Month 38: 33 views
Month 39: 31 views
Month 40: 17 views
Month 41: 18 views
Month 42: 37 views
Month 43: 16 views
Month 44: 32 views
Month 45: 41 views
Month 46: 37 views
Month 47: 39 views
Month 48: 21 views
Month 49: 39 views
Month 50: 25 views
Month 51: 16 views
Month 52: 16 views
Month 53: 28 views
Month 54: 38 views
Month 55: 15 views
Month 56: 29 views
Month 57: 23 views
Month 58: 22 views
Month 59: 27 views
Month 60: 33 views
Month 61: 37 views
Month 62: 28 views
Month 63: 18 views
Month 64: 22 views
Month 65: 25 views
Month 66: 22 views
Month 67: 35 views
Month 68: 36 views
Month 69: 38 views
Month 70: 32 views
Month 71: 37 views
Month 72: 27 views
Month 73: 30 views
Month 74: 36 views
Month 75: 27 views
Month 76: 23 views
Month 77: 22 views
Month 78: 35 views
Month 79: 36 views
Month 80: 34 views
Month 81: 35 views
Month 82: 45 views
Month 83: 35 views
Month 84: 33 views
Month 85: 39 views
Month 86: 21 views
Month 87: 31 views
Month 88: 33 views
Month 89: 14 views
Month 90: 24 views
Month 91: 23 views
Month 92: 21 views
Month 93: 29 views
Month 94: 40 views
Month 95: 27 views
Month 96: 18 views
Month 97: 34 views
Month 98: 18 views
Month 99: 40 views
Month 100: 20 views
Month 101: 31 views
Month 102: 47 views
Month 103: 33 views
Month 104: 33 views
Month 105: 25 views
Month 106: 28 views
Month 107: 32 views
Month 108: 30 views
Month 109: 11 views
Month 110: 31 views
Month 111: 17 views
Month 112: 43 views
Month 113: 39 views
Month 114: 28 views
Month 115: 43 views
Month 116: 67 views
Month 117: 33 views
Month 118: 32 views
Month 119: 44 views

Total Views: 3759

Total Downloads: 1817

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]