The Flat Panel Volumetric Computed Tomography in in vivo Tissue Engineering of Bone: Possibilities and Limitations

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Stefan Endres
Stefan Endres
2
Christian Beltzer
Christian Beltzer
1 UniversitAtsklinikum Hamburg Eppendorf

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The scaffold-based tissue engineering of bones is an extremely promising concept with regard to the regeneration of major bone defects due to trauma, tumour or developmental abnormalities as well as for the treatment of pseudo-arthroses. The in vivo testing of implants is a significant phase in the development of specimens for the clinical application of suitable scaffolds. The collection of an optimal amount of information from these initial -clinical -tests demands, ideally, the most diagnostically conclusive studies possible. We tested the procedure of flat panel volumetric computer tomography (fpvCT) thus far virtually untried in the area of bone tissue engineering for the in vivo evaluation of small animal experiments and compared it with other methods (projection radiography, micro-CT, histology).

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

Stefan Endres. 2015. \u201cThe Flat Panel Volumetric Computed Tomography in in vivo Tissue Engineering of Bone: Possibilities and Limitations\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 15 (GJMR Volume 15 Issue K2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-K Classification: NLMC Code: WG 141.5.T6
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April 24, 2015

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English

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The scaffold-based tissue engineering of bones is an extremely promising concept with regard to the regeneration of major bone defects due to trauma, tumour or developmental abnormalities as well as for the treatment of pseudo-arthroses. The in vivo testing of implants is a significant phase in the development of specimens for the clinical application of suitable scaffolds. The collection of an optimal amount of information from these initial -clinical -tests demands, ideally, the most diagnostically conclusive studies possible. We tested the procedure of flat panel volumetric computer tomography (fpvCT) thus far virtually untried in the area of bone tissue engineering for the in vivo evaluation of small animal experiments and compared it with other methods (projection radiography, micro-CT, histology).

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The Flat Panel Volumetric Computed Tomography in in vivo Tissue Engineering of Bone: Possibilities and Limitations

Christian Beltzer
Christian Beltzer
Stefan Endres
Stefan Endres UniversitAtsklinikum Hamburg Eppendorf

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