The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

1
hara masa
hara masa
2
Masayasu Hara
Masayasu Hara
3
Takaya Nagasaki
Takaya Nagasaki
4
Hiromitsu Takeyama
Hiromitsu Takeyama
1 Nagoya City University

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GJMR Volume 13 Issue I3

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The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo Banner
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Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been widely used for therapy of several kinds of malignant diseases. However, the anticancer effect is incomplete. The purpose of this study was to examine the synergism between the herbal drug, Polysaccharide K, and Cetuximab against gastrointestinal cancer cell lines in vitro and in vivo. Two gastrointestinal cancer cell lines positive for EGFR expression were used for this study. In the in vivo study, mice were xenografted with cancer cell lines subcutaneously. Neither PSK nor Cetuximab suppressed cell proliferation. However, when both drugs were administered, cancer growth was suppressed significantly compared with treatment with Cetuximab alone. This study demonstrated that PSK has the potential to enhance Cetuximab’s effect on gastrointestinal cancer.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

hara masa. 2013. \u201cThe Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo\u201d. Unknown Journal GJMR-I Volume 13 (GJMR Volume 13 Issue I3): .

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October 31, 2013

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Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been widely used for therapy of several kinds of malignant diseases. However, the anticancer effect is incomplete. The purpose of this study was to examine the synergism between the herbal drug, Polysaccharide K, and Cetuximab against gastrointestinal cancer cell lines in vitro and in vivo. Two gastrointestinal cancer cell lines positive for EGFR expression were used for this study. In the in vivo study, mice were xenografted with cancer cell lines subcutaneously. Neither PSK nor Cetuximab suppressed cell proliferation. However, when both drugs were administered, cancer growth was suppressed significantly compared with treatment with Cetuximab alone. This study demonstrated that PSK has the potential to enhance Cetuximab’s effect on gastrointestinal cancer.

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The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

Masayasu Hara
Masayasu Hara
Takaya Nagasaki
Takaya Nagasaki
Hiromitsu Takeyama
Hiromitsu Takeyama

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