The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

hara masa

The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

hara masa * §

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mshara

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[email protected]

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Nagoya City University

The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

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Abstract

Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been widely used for therapy of several kinds of malignant diseases. However, the anticancer effect is incomplete. The purpose of this study was to examine the synergism between the herbal drug, Polysaccharide K, and Cetuximab against gastrointestinal cancer cell lines in vitro and in vivo. Two gastrointestinal cancer cell lines positive for EGFR expression were used for this study. In the in vivo study, mice were xenografted with cancer cell lines subcutaneously. Neither PSK nor Cetuximab suppressed cell proliferation. However, when both drugs were administered, cancer growth was suppressed significantly compared with treatment with Cetuximab alone. This study demonstrated that PSK has the potential to enhance Cetuximab’s effect on gastrointestinal cancer.

References

14 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

hara masa, mshara, [email protected]. 2013. "The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo". Global Journal of Medical Research - I: Surgeries & Cardiovascular System GJMR-I Volume 13 (GJMR Volume 13 Issue I3).

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GJMR Volume 13 Issue I3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-I Classification NLMC Code: WB 925

QU 83

Submission ReceivedApril 5, 2013
Peer Review Double Blind
Handling Editor
Accepted May 4, 2013
Published May 15, 2013

Version of record

v1.2

Issue date

October 31, 2013

Language

English

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Article Matrices

Total Score: 188

Country: Japan

Subject: Global Journal of Medical Research

Authors: Masayasu Hara, Takaya Nagasaki, Hiromitsu Takeyama (PhD/Dr. count: 0)

View Count (all-time): 261

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Publish Date: 2013 05, Wed

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Total Views: 1.9K

Total Downloads: 130

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