The Impact of Senna Siamea (Lam) leaves extracts on 2, 2-Dichlorovinyldimethyl Phosphate Induced Brain Oxidative Stress in Wistar Albino Rats

Oni, Olaiya Peter; Oseni, Olatunde Abass; Okoh, Olayinka Sunday

The Impact of Senna Siamea (Lam) leaves extracts on 2, 2-Dichlorovinyldimethyl Phosphate Induced Brain Oxidative Stress in Wistar Albino Rats

Oni, Olaiya Peter * §

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Oseni, Olatunde Abass

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Okoh, Olayinka Sunday

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Ekiti-State University

The Impact of Senna Siamea (Lam) leaves extracts on 2, 2-Dichlorovinyldimethyl Phosphate Induced Brain Oxidative Stress in Wistar Albino Rats

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Abstract

Organophosphate compounds have been a common source of mortality in recent times. A typical example is dichlorvos [2, 2-Dichlorovinyldimethylphosphate (DDVP)]; an important agricultural pesticide. This study sought to investigate the phytochemical screening, invitro antioxidant property of the leaf solvents extracts and ameliorating effects of Senna siameain DDVP-induced brain oxidative stress in Wistar rats. The aqueous, methanol and ethanol extracts of the leaves were obtained and analyzed for their in-vitro antioxidant parameters. Thirty-two healthy Wistar albino rats were grouped into eight of 4rats each weighing between 140-150g. The animals were orally administered with 6.6mg/kg body weight of DDVP except groups1 and 2 followed by treatments with the three solvents extracts respectively that lasted for four weeks.

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The authors declare no conflict of interest.

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How to Cite This Article

Oni, Olaiya Peter, Oseni, Olatunde Abass, Okoh, Olayinka Sunday. 2021. "The Impact of Senna Siamea (Lam) leaves extracts on 2, 2-Dichlorovinyldimethyl Phosphate Induced Brain Oxidative Stress in Wistar Albino Rats". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 21 (GJMR Volume 21 Issue B3).

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GJMR Volume 21 Issue B3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: WB 340

Submission ReceivedJune 12, 2021
Peer Review Double Blind
Handling Editor
Accepted June 30, 2021
Published July 15, 2021

Version of record

v1.2

Issue date

October 27, 2021

Language

English

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