The Proteins of Type IV Secretion System as Promising Candidates for Helicobacter Pylori Vaccine

Davood Esmaeili

The Proteins of Type IV Secretion System as Promising Candidates for Helicobacter Pylori Vaccine

Davood Esmaeili * §

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Mashhad University of Medical Sciences

The Proteins of Type IV Secretion System as Promising Candidates for Helicobacter Pylori Vaccine

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Abstract

Helicobacter. pylori is a component of class 1 carcinogens and there is a close association between the incidence of gastric cancer and high prevalence of infection with this bacterium. The risk of gastric cancer associated with H. pylori infection in industrialized and developing countries is estimated to be 80% and 70% respectively. CagA is the important virulence factor in this bacterium and all of the strains involved in gastric cancer are CagA positive. This factor is secreted into host cells by type IV secretion system. CagA and type IV secretion system in H. pylori encoded by the cag pathogenicity islands (cag PAI) that encodes 30 proteins which are necessary for the pilus formation and function of type IV secretion system, so regarding to the role of this secretion system in secreting CagA and its function in pathogenesis and cancer development in humans and the role of different proteins of this secretion system such as canal and pilus formation and their necessity for function of these structures, it is possibly they are be appropriate candidates for design vaccine, because with inhibiting these proteins can stop canal and pilus formation and finally hinder CagA secretion into the host cells.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Davood Esmaeili. 2015. "The Proteins of Type IV Secretion System as Promising Candidates for Helicobacter Pylori Vaccine". Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 15 (GJMR Volume 15 Issue C3).

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GJMR Volume 15 Issue C3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-C Classification NLMC Code: WI 387

Submission ReceivedDecember 12, 2014
Peer Review Double Blind
Handling Editor
Accepted January 2, 2015
Published January 15, 2015

Version of record

v1.2

Issue date

August 28, 2015

Language

English

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Article Matrices

Total Score: 123

Country: Iran

Subject: Global Journal of Medical Research

Authors: Azad Khaledi, Abbas Bahador, Davood Esmaeili (PhD/Dr. count: 0)

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