The S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects On Cytokines Expression in Liver Disease Progression

The S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects On Cytokines Expression in Liver Disease Progression

Hussein Mukasa Kafeero

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Abubaker Kawooya

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Mariam Namusoke

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Saad Atiku

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Joseph Mugambwa

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Makerere University

The S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects On Cytokines Expression in Liver Disease Progression

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Abstract

The causal agent for hepatitis B is called hepatitis B virus (HBV). It is a partially double stranded circular DNA virus of the family Hepadnaviridae. It has been implicated as the leading cause of hepatocellular carcinoma and only second to tobacco among the global human carcinogens. Liver damage as a result of HBV infection is due to host immune response and is modulate by cytokines. The HBV is classified into 10 genotype denoted as A, B, C, D, E, F, G, H, I and J together with several sub-genotypes which have diverse geographical distribution. These genotypes influence liver disease progression and severity as well as response to antiviral therapies. Mutations in the S-gene have been implicated in the paradoxical coexistence of HBsAg and the anti-HBs antibodies which is associated with advanced liver diseases including hepatocellular carcinoma and liver cirrhosis.

References

61 Cites in Article

Reference Format

Ahmad Al-Mulla,Maznah Al-Mutairi,Fawzia Ashkanani,Mohammed Algazar,Mohammed Abdelhamid,Nouf Al Alenezi (2015). Para-Duodenal Hernia Unusual Presentation of Abdominal Obstruction: A Case Report.
N Akpolat,S Yahsi,A Godekmerdan,K Demirbag,M Yalniz (2005). Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B.
W Alazawi,G Foster (2008). Advances in the diagnosis and treatment of hepatitis B.
P Arauz-Ruiz,H Norder,B Robertson,L Magnius (2002). Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America.
D Atuhaire,M Afayo,S Ochwo,D Katiti,F Mwiine,A Nanteza,L Ojok (2014). Comparative detection of African swine fever virus by loop-mediated isothermal amplification assay and polymerase chain reaction in do mestic pigs in Uganda.
Rym Ayari,Yousr Lakhoua-Gorgi,Lamjed Bouslama,Imen Safar,Fatma Kchouk,Houda Aouadi,Saloua Jendoubi-Ayed,Taoufik Najjar,Kaled Ayed,Taieb Abdallah (2012). Investigation of DNA Sequence in the Basal Core Promoter, Precore, and Core Regions of Hepatitis B Virus from Tunisia Shows a Shift in Genotype Prevalence.
Warda Baha,My Ennaji,Fatiha Lazar,Marouane Melloul,Elmostafa El Fahime,Abdelouahad El Malki,Abdelouaheb Bennani (2012). HBV genotypes prevalence, precore and basal core mutants in Morocco.
A Caliendo,A Valsamakis,J Bremer (2011). Multilaboratory evaluation of real-time PCR tests for hepatitis B virus DNA quantification.
G Cao (2009). Clinical relevance and public health significance of hepatitis B virus genomic variations.
Chi–jen Chu,Munira Hussain,Anna Lok (2002). Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C.
Paul Coleman (2006). Detecting Hepatitis B Surface Antigen Mutants.
W Cooksley (2010). Do we need to determine viral genotype in treating chronic hepatitis B?.
F Ding,X Miao,Y Li,J Dai,H Yu (2015). Original article Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and.
Linda Dunford,Michael Carr,Jonathan Dean,Linh Nguyen,Thu Ta Thi,Binh Nguyen,Jeff Connell,Suzie Coughlan,Hien Nguyen,William Hall,Lan Thi (2012). A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam.
Paulo Ferreira,Simone Tenore (2010). Response predictors to treatment with pegylated interferon in chronic hepatitis B.
N Fierro,K González-Aldaco,R Torres-Valadez,M Trujillo-Trujillo,S Roman,J Trujillo-Ochoa,A Panduro (2015). Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients.
Nora Fierro,Sonia Roman,Mauricio Realpe,Zamira Hernandez-Nazara,Eloy Zepeda-Carrillo,Arturo Panduro (2011). Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients.
Elisabetta Franco,B Bagnato,M Giulia,C Maleleo,S Laura,Z Laura (2012). Hepatitis B: Epidemiology and prevention in developing countries.
Angela Frodsham,Lyna Zhang,Uga Dumpis,Nor Taib,Steve Best,Andrew Durham,Branwen Hennig,Simon Hellier,Susanne Knapp,Mark Wright,Maria Chiaramonte,John Bell,Mary Graves,Hilton Whittle,Howard Thomas,Mark Thursz,Adrian Hill (2006). Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
H Hopkins,I González,S Polley,P Angutoko,J Ategeka,C Asiimwe,D Bell (2013). Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda.
Harry Janssen,Monika Van Zonneveld,Hakan Senturk,Stefan Zeuzem,Ulus Akarca,Yilmaz Cakaloglu,Christopher Simon,Thomas So,Guido Gerken,Robert De Man,Hubert Niesters,Pieter Zondervan,Bettina Hansen,Solko Schalm (2005). Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial.
H Kafeero,M Frank,N Mwiine,D Kalenzi,A Sylvester,O Nanteza (2016). Review for "A reverse transcription loop‐mediated isothermal amplification assay for the detection of strawberry mottle virus".
Kahila Bar-Gal,G Kim,M Klein,A Shin,D Oh,C Kim,J Shouval,D (2012). Tracing hepatitis B virus to the 16th century in a Korean mummy.
Jia-Horng Kao (2008). Diagnosis of hepatitis B virus infection through serological and virological markers.
J Kao,P Chen,M Lai,D Chen (2002). Genotypes and Clinical Phenotypes of Hepatitis B Virus in Patients with Chronic Hepatitis B Virus Infection.
S Keating,J Heitman,S Wu,X Deng,S Stramer,M Kuhns,C Mullen,P Norris,M Busch (2014). Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naive and Previously Vaccinated Blood and Plasma Donors.
Woottichai Khamduang,Nicole Ngo-Giang-Huong,Catherine Gaudy-Graffin,Gonzague Jourdain,Weerapong Suwankornsakul,Tapnarong Jarupanich,Veeradate Chalermpolprapa,Sirisak Nanta,Noossara Puarattana-Aroonkorn,Sakchai Tonmat,Marc Lallemant,Alain Goudeau,Wasna Sirirungsi (2013). Prevalence, Risk Factors, and Impact of Isolated Antibody to Hepatitis B Core Antigen and Occult Hepatitis B Virus Infection in HIV-1–Infected Pregnant Women.
Mariko Kobayashi,Yasuji Arase,Kenji Ikeda,Akihito Tsubota,Yoshiyuki Suzuki,Satoshi Saitoh,Masahiro Kobayashi,Fumitaka Suzuki,Norio Akuta,Takashi Someya,Marie Matsuda,Junko Sato,Hiromitsu Kumada (2002). Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.
Narcisse Komas,Ulrich Vickos,Judith Hübschen,Aubin Béré,Alexandre Manirakiza,Claude Muller,Alain Le Faou (2013). Cross-sectional study of hepatitis B virus infection in rural communities, Central African Republic.
Fuat Kurbanov,Yasuhito Tanaka,Kei Fujiwara,Fuminaka Sugauchi,Dora Mbanya,Leopold Zekeng,Nicaise Ndembi,Charlotte Ngansop,Lazare Kaptue,Tomoyuki Miura,Eiji Ido,Masanori Hayami,Hiroshi Ichimura,Masashi Mizokami (2005). A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon.
Fuat Kurbanov,Yasuhito Tanaka,Masashi Mizokami (2010). Geographical and genetic diversity of the human hepatitis B virus.
C Lin,J Kao (2011). The clinical implications of hepatitis B virus genotype.
Chih‐lin Lin,Jia‐horng Kao (2011). The clinical implications of hepatitis B virus genotype: Recent advances.
Enock Matovu,Irene Kuepfer,Alex Boobo,Stafford Kibona,Christian Burri (2010). Comparative Detection of Trypanosomal DNA by Loop-Mediated Isothermal Amplification and PCR from Flinders Technology Associates Cards Spotted with Patient Blood.
K Matsuura,Y Tanaka,S Hige,G Yamada,Y Murawaki,M Komatsu,M Mizokami (2009). Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A.
G Matthews,E Seaberg,A Avihingsanon,S Bowden,G Dore,S Lewin,C Thio (2013). Patterns and Causes of Suboptimal Response to Tenofovir-Based Therapy in Individuals Coinfected With HIV and.
Brian Mcmahon (2009). The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B.
C Mullis,O Laeyendecker,S Reynolds,P Ocama,J Quinn,I Boaz,R Gray,G Kirk,D Thomas,T Quinn,L Stabinski (2013). High Frequency of False-Positive Hepatitis C Virus Enzyme-Linked Immunosorbent Assay in Rakai, Uganda.
T Notomi,H Okayama,H Masubuchi,T Yonekawa,K Watanabe,N Amino,T Hase (2000). Loop-mediated isothermal amplification of DNA.
D-C Nyan,L Ulitzky,N Cehan,P Williamson,V Winkelman,M Rios,D Taylor (2014). Rapid Detection of Hepatitis B Virus in Blood Plasma by a Specific and Sensitive Loop-Mediated Isothermal Amplification Assay.
Emmanuel Ochola,Ponsiano Ocama,Christopher Orach,Ziadah Nankinga,Joan Kalyango,Willi Mcfarland,Charles Karamagi (2013). High burden of hepatitis B infection in Northern Uganda: results of a population-based survey.
J Ott,G Stevens,J Groegar,S Wiersma (2012). Global epidemiology of hepatitis B virusinfection: New estimates of age specific HBsAg seroprevalence and endemicity.
B Pido,M Kagimu (2005). Prevalence of Hepatitis B Virus (HBV) infection among Makerere University medical students.
J Quer,M Martell,F Rodriguez,A Bosch,R Jardi,M Buti,J Esteban (2008). The Impact of Rapid Evolution of Hepatitis Viruses.
V Racanelli,B Rehermann (2006). The liver as an immunological organ.
M Ragheb,A Elkady,Y Tanaka,S Murakami,F Attia,A Hassan,A Khan (2012). Multiple intrafamilial transmission patterns of hepatitis B virus genotype D in north-eastern Egypt.
J Sanchez-Tapias,J Costa,A Mas,M Bruguera,J Rodes (2002). Influence of hepatitis B virus genome on the long-term outcome of chronic hepatitis B virus in western patients.
Seung Seo,Hyeok Choi,Bo Choi,Hyoung Kim,Hak Kim,Myoung Jang (2014). Coexistence of hepatitis B surface antigen and antibody to hepatitis B surface may increase the risk of hepatocellular carcinoma in chronic hepatitis B virus infection: A retrospective cohort study.
Ying-Hui Shi (2012). Correlation between Hepatitis B Virus Genotypes and Clinical Outcomes.
Ekachai Singhatiraj,Joshan Suri,Claudia Goulston (2012). HIV Co-Infections with Hepatitis B and C.
J Suppiah,R Mohd Zain,N Bahari,S Haji Nawi,Z Saat (2014). S gene mutants occurrence among hepatitis B carriers in malaysia.
Valentina Svicher,Valeria Cento,Romina Salpini,Fabio Mercurio,Maria Fraune,Bastian Beggel,Yue Han,Caterina Gori,Linda Wittkop,Ada Bertoli,Valeria Micheli,Guido Gubertini,Roberta Longo,Sara Romano,Michela Visca,Valentina Gallinaro,Nicoletta Marino,Francesco Mazzotta,Giuseppe De Sanctis,Hervè Fleury,Pascale Trimoulet,Mario Angelico,Giuseppina Cappiello,Xin Zhang,Jens Verheyen,Francesca Ceccherini-Silberstein,Carlo Perno (2011). Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.
Yasuhito Tanaka,Izumi Hasegawa,Takanobu Kato,Etsuro Orito,Noboru Hirashima,Subrat Acharya,Robert Gish,Anna Kramvis,Michael Kew,Namiko Yoshihara,Santosh Shrestha,Mobin Khan,Yuzo Miyakawa,Masashi Mizokami (2004). A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D †.
C Thio (2009). Hepatitis B human immunodeficiency viruscoinfection.
Chun Wai,Chi-Jen Chu,Munira Hussain,Anna Lok (2002). HBV genotype B is associated with better response to interferon therapy in HBeAg( + ) chronic hepatitis than genotype C.
Fu-Sheng Wang,Zheng Zhang (2009). Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus.
Edward Watson-Williams,Peter Kataaha (1990). Revival of the Ugandan Blood Transfusion system 1989: an example of international cooperation.
Who (2004). World Health Organization, author. Hepatitis B Vaccines.
Mukhlid Yousif,Anna Kramvis (2013). Genotype <scp>D</scp> of hepatitis <scp>B</scp> virus and its subgenotypes: An update.
M Yuen,E Sablon,D Wong,H Yuan,B Wong,A Chan,C Lai (2003). Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation.
Q Zhang,W Qi,X Wang,Y Zhang,Y Xu,S Qin,S Ji (2016). Epidemiology of Hepatitis B and Hepatitis C Infections and Bene fi ts of Programs for Hepatitis Prevention in Northeastern China : A Cross-Sectional Study.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

Hussein Mukasa Kafeero. 2016. \u201cThe S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects On Cytokines Expression in Liver Disease Progression\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 16 (GJMR Volume 16 Issue C2): .

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GJMR Volume 16 Issue C2
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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-C Classification: NLMC Code: QW 170

Submission ReceivedDecember 15, 2015
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Accepted January 5, 2016
Published January 15, 2016

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Total Score: 105

Country: Uganda

Subject: Global Journal of Medical Research - C: Microbiology & Pathology

Authors: Hussein Mukasa Kafeero, Abubaker Kawooya, Mariam Namusoke, Saad Atiku, Joseph Mugambwa (PhD/Dr. count: 0)

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