The Unique Australian Flora, A Veritable Pandora’s Pharmacopeia of Compounds with Therapeutic Biomedical Potential: Are the Chalcones the Geni in The Box?

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James Melrose
James Melrose
1 University of New South Wales Sydney

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The aim of this review was to highlight the unique biodiversity of the flowering plants and shrubs of Australia and their component chemicals that evolved during the separation of the Australian continent from Gondwanaland. The chemicals produced by these flowering plants provided protection ensuring the survival of the Australian flora which had to contend with often harsh Australian climatic conditions. The diversity of plant phytochemicals produced by these flowering plants reflects the unique diversity of the Australian Flora and these represent a Pharmacological goldmine. It was beyond the scope of this review to cover the full spectrum of these chemical compounds present in Australian plants instead we focused on the chalcones in this review. This compound has a special status in medicinal chemistry as a base intermediate for the synthesis of a large repertoire of polycyclic compounds that display anti-bacterial, antifungal, anti-viral and anti-tumour properties and these are thus of considerable interest in Biomedicine.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

James Melrose. 2021. \u201cThe Unique Australian Flora, A Veritable Pandora’s Pharmacopeia of Compounds with Therapeutic Biomedical Potential: Are the Chalcones the Geni in The Box?\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 21 (GJSFR Volume 21 Issue B1): .

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Issue Cover
GJSFR Volume 21 Issue B1
Pg. 77- 97
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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-B Classification: FOR Code: 090399
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v1.2

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March 30, 2021

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English

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The aim of this review was to highlight the unique biodiversity of the flowering plants and shrubs of Australia and their component chemicals that evolved during the separation of the Australian continent from Gondwanaland. The chemicals produced by these flowering plants provided protection ensuring the survival of the Australian flora which had to contend with often harsh Australian climatic conditions. The diversity of plant phytochemicals produced by these flowering plants reflects the unique diversity of the Australian Flora and these represent a Pharmacological goldmine. It was beyond the scope of this review to cover the full spectrum of these chemical compounds present in Australian plants instead we focused on the chalcones in this review. This compound has a special status in medicinal chemistry as a base intermediate for the synthesis of a large repertoire of polycyclic compounds that display anti-bacterial, antifungal, anti-viral and anti-tumour properties and these are thus of considerable interest in Biomedicine.

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The Unique Australian Flora, A Veritable Pandora’s Pharmacopeia of Compounds with Therapeutic Biomedical Potential: Are the Chalcones the Geni in The Box?

James Melrose
James Melrose University of New South Wales Sydney

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