Tranexamic Acid Coated or Eluted Uterine Balloon and Co- Attached Cervical Shutter in Post Partum Haemorrhage. A New Combatant in the Armamentarium, Not Merely a Balloon but More

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Abd El Aal Nasser Kamal
Abd El Aal Nasser Kamal

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Tranexamic Acid Coated or Eluted Uterine Balloon and Co- Attached Cervical Shutter in Post Partum Haemorrhage. A New Combatant in the Armamentarium, Not Merely a Balloon but More

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Tranexamic Acid Coated or Eluted Uterine Balloon and Co- Attached Cervical Shutter in Post Partum Haemorrhage. A New Combatant in the Armamentarium, Not Merely a Balloon but More Banner

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Abstract

Described herein a Tranexamic Acid (TXA) -Coated or Eluted Uterine Balloon for use in an intra uterine location for primary management of postpartum haemorrhage (PPH). It enforces the tamponade effect of currently used non medicated uterine balloons with an additional inbuilt mechanism of local steady release of the antibrinolytic TXA into uterine cavity that has been evidenced to contribute to haemostasis in cases of PPH. The invention ushers a new era of utilizing the uterine balloon surface coat as a delivery vehicle for TXA. This can be achieved via different techniques including and not limited to matrix coating or eluting of nanoparticulate TXA in the outermost layer of the balloon .TXA coated or eluted balloon replenish non medicated balloons with a therapeutic modality of the TXA relatedantifibrinolysis especially in hemorrhages known to be associated with coagulopathy.

References

13 Cites in Article
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  7. W Chantrapitak,K Srijuntuek,R Wattanaluangarun (2011). The efficacy of lower uterine segment compression for prevention of early postpartum hemorrhage after vaginal delivery.
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  9. K Ker,P Edwards,P Perel,H Shakur,I Roberts (2012). Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
  10. H Shakur,I Roberts,R Bautista (2010). Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
  11. Andrea Dell’amore,Guido Caroli,Asadi Nizar,Nicola Cassanelli,Giulia Luciano,Domenico Greco,Giampiero Dolci,Alessandro Bini,Franco Stella (2012). Can Topical Application of Tranexamic Acid Reduce Blood Loss in Thoracic Surgery? A Prospective Randomised Double Blind Investigation.
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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Abd El Aal Nasser Kamal. 2018. \u201cTranexamic Acid Coated or Eluted Uterine Balloon and Co- Attached Cervical Shutter in Post Partum Haemorrhage. A New Combatant in the Armamentarium, Not Merely a Balloon but More\u201d. Global Journal of Medical Research - E: Gynecology & Obstetrics GJMR-E Volume 18 (GJMR Volume 18 Issue E4): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-E Classification: NLMC Code: WP 440
Version of record

v1.2

Issue date

December 19, 2018

Language
en
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Described herein a Tranexamic Acid (TXA) -Coated or Eluted Uterine Balloon for use in an intra uterine location for primary management of postpartum haemorrhage (PPH). It enforces the tamponade effect of currently used non medicated uterine balloons with an additional inbuilt mechanism of local steady release of the antibrinolytic TXA into uterine cavity that has been evidenced to contribute to haemostasis in cases of PPH. The invention ushers a new era of utilizing the uterine balloon surface coat as a delivery vehicle for TXA. This can be achieved via different techniques including and not limited to matrix coating or eluting of nanoparticulate TXA in the outermost layer of the balloon .TXA coated or eluted balloon replenish non medicated balloons with a therapeutic modality of the TXA relatedantifibrinolysis especially in hemorrhages known to be associated with coagulopathy.

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Tranexamic Acid Coated or Eluted Uterine Balloon and Co- Attached Cervical Shutter in Post Partum Haemorrhage. A New Combatant in the Armamentarium, Not Merely a Balloon but More

Abd El Aal Nasser Kamal
Abd El Aal Nasser Kamal

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