Urinary Excretion and Renal Clearance of Allopurinol in Male Gout Patients

Urinary Excretion and Renal Clearance of Allopurinol in Male Gout Patients

Bilal Ahmed Ph.D.

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Tahira Iqbal

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Farah Latif and Imtiaz Sohail.

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University of Agriculture Faisalabad

Urinary Excretion and Renal Clearance of Allopurinol in Male Gout Patients

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Abstract

Drugs removed from the body either without changing from its original form or in the form of its metabolite. Allopurinol drug decreases uric acid level in blood and it is used for the treatment of gout and tumor lysis syndrome. Allopurinol and its active metabolite oxipurinol stop the function of xanthine oxidase which forms uric acid from xanthine and hypoxanthine. In this study a quantitative assay using high-performance liquid chromatography (HPLC) with UVdetection was used as a method for quantification of allopurinol and oxipurinol in human serum and urine samples of gout patients after allopurinol administration. The urinary excretion and renal clearance was determined in male gout patients. Blood and urine samples of the human male patients of gout (n=10) after the oral administration of 300mg drug were taken at different time intervals. Results of this study show that there is slow metabolism of allopurinol inside body due to its extensive bonding with blood proteins. Statistical analysis was performed by expressing all the data as mean and ± standard error of mean. The effect of pH and diuresis on renal clearance of allopurinol was studied by regression analysis.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Bilal Ahmed. 2014. \u201cUrinary Excretion and Renal Clearance of Allopurinol in Male Gout Patients\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 13 (GJMR Volume 13 Issue F6): .

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GJMR Volume 13 Issue F6
Pg. 5- 13

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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Submission ReceivedFebruary 3, 2013
Peer Review Double Blind
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Accepted March 3, 2013
Published March 15, 2013

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v1.2

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February 9, 2014

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Total Score: 103

Country: Unknown

Subject: Global Journal of Medical Research - F: Diseases

Authors: Bilal Ahmed, Tahira Iqbal, Farah Latif and Imtiaz Sohail. (PhD/Dr. count: 0)

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