Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

Bilal Ahmed Ph.D.

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Tahira Iqbal

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Huma Mahboob

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Farah Latif

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Imtiaz Sohail.

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University of Agriculture Faisalabad

Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

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Abstract

Drugs are eliminated from the body either unchanged as the parent drug or as metabolites. Nimesulide drug belongs to a wide class of medicines called antiinflammatory nonsteroidal drugs (NSAID). NSAIDs are well known for their antipyretic, anti-inflammatory, and analgesic properties. Renal clearance of nimesulide correlated with creatinine clearance. The present research work was planed to determine urinary excretion and renal clearance of nimesulide after its oral administration. Blood and urine samples of the human male volunteers (n=10), after the oral administration of drug, were collected at predetermined time intervals. The concentration of the nimesulide in urine and plasma of male volunteers was determined by HPLC. Statistical analysis was performed in order to determine the significance of the results.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Bilal Ahmed. 2014. \u201cUrinary Excretion and Renal Clearance of Nimesulide in Male Volunteers\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B1): .

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GJMR Volume 14 Issue B1
Pg. 23- 27

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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Submission ReceivedDecember 6, 2013
Peer Review Double Blind
Handling Editor
Accepted January 4, 2014
Published January 15, 2014

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v1.2

Issue date

March 20, 2014

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Article Matrices

Total Score: 105

Country: Unknown

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Bilal Ahmed, Tahira Iqbal, Huma Mahboob, Farah Latif, Imtiaz Sohail. (PhD/Dr. count: 0)

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