Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
February 17, 2026
Neural Networks and Rules-based Systems used to Find Rational and
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Blockage of PD-1 proteins by immune checkpoint inhibitors showed an accepted therapeutic effect in cancer. But; tumor microenvironment exerts its antitumor influence by various mechanisms. Malignant cells have the ability of PD-1/PD-L1 protein over synthesis, which can be a defense action against immune checkpoint inhibitors and immunotherapy. Binding nivolumab with platinum-containing STAT1 will be used to reduce PD-1 genetic level. Nivolumab has the option of endocytosis, while STAT1 is the transcription factor that binds to the DNA, specifically PD-1 gene. STAT1 is the activated protein in response to multiple cytokines stimulation of cancer cells, which are the same for increasing PD-1/ PD-L1 upregulation. The used STAT1 in our therapeutic strategy is the activated form and loaded with platinum particles for damaging DNA bases in PD-1 promoter regions upon translocation to the nucleus. STAT1platinum molecule is connected to nivolumab Fc region by solamargine polymer for selective cancer cell targeting.
Waleed O. Atta. 2026. \u201cUsage of Nivolumab – Platinum Containing STAT1 Molecule for Suppression PD-1/PD-L1 Genes in PD-1/PD-L1 Expressing Cancer Cells\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 22 (GJMR Volume 22 Issue B2): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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Blockage of PD-1 proteins by immune checkpoint inhibitors showed an accepted therapeutic effect in cancer. But; tumor microenvironment exerts its antitumor influence by various mechanisms. Malignant cells have the ability of PD-1/PD-L1 protein over synthesis, which can be a defense action against immune checkpoint inhibitors and immunotherapy. Binding nivolumab with platinum-containing STAT1 will be used to reduce PD-1 genetic level. Nivolumab has the option of endocytosis, while STAT1 is the transcription factor that binds to the DNA, specifically PD-1 gene. STAT1 is the activated protein in response to multiple cytokines stimulation of cancer cells, which are the same for increasing PD-1/ PD-L1 upregulation. The used STAT1 in our therapeutic strategy is the activated form and loaded with platinum particles for damaging DNA bases in PD-1 promoter regions upon translocation to the nucleus. STAT1platinum molecule is connected to nivolumab Fc region by solamargine polymer for selective cancer cell targeting.
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