Use of Intravenous Clonidine Vs Placebo for Prolonging Spinal Anaesthesia

Use of Intravenous Clonidine Vs Placebo for Prolonging Spinal Anaesthesia

Dr Prerana Shah

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Prerana Nirav Shah

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Devanand Pawar

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Use of Intravenous Clonidine Vs Placebo for Prolonging Spinal Anaesthesia

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Abstract

Use of intravenous clonidine for prolonging spinal anaesthesia with bupivacaine. Background: Several additives like clonidine are added to prolong spinal blockade. We considered using clonidine through intravenous route as it achieves peak plasma concentration more rapidly than oral or intrathecal routes. The aim was to study onset of analgesia and duration of sensory and motor blockade after spinal anaesthesia. Methods: Our study was a double blind prospective randomized controlled type of 100 patients. In clonidine group, intravenous 3 mcg/ kg of Clonidine diluted in 10ml of normal saline was administered after making the patient supine following the spinal blockade. In saline group, intravenous 10 ml of normal saline was administered. Patients were monitored until the sensory block regressed below L1 dermatome and knee flexion had recovered. Heart rate and mean arterial pressure were measured.

References

16 Cites in Article

Reference Format

J M Moore,S S Liu,J E Pollock,J M Neal,J H Knab (1998). The effect of epinephrine on small dose hyperbaric bupivacaine spinal anaesthesia. Clinical implications for ambulatory surgery.
Mercedes Conception,Rosemarie Maddi,Deborah Francis,Angelo Rocco,Ellen Murray,Benjamin Covino (1984). Vasoconstrictors in Spinal Anesthesia with Tetracaine???A Comparison of Epinephrine and Phenylephrine.
Katsuya Mikawa,Kahoru Nishina,Nobuhiro Maekawa,Hidefumi Obara (1996). Oral Clonidine Premedication Reduces Postoperative Pain in Children.
L Niemi (1994). Effects of intrathecal clonidine on duration bupivacaine of spinal anaesthesia, haemodynamics and post operative analgesia in patients undergoing knee arthroscopy.
F Bonnet,P Catoire,Brun Buisson,M Saada,Y Francois (1990). Effects of Oral and Subarachnoid Clonidine on Spinal Anesthesia with Bupivacaine.
K Rhee,S Kang,Kin,Y Jeon (2003). Intravenous clonidine prolongs bupivacaine spinal anaesthesia.
J Bonica,P Backup (1950). Intrathecal use of vasoconstrictors to prolong spinal anesthesia.
Sharvari Jagadale (2007). Intravenous Dexmedetomidine vs. Intravenous Clonidine to Prolong Bupivacaine Spinal anaesthesia.
I Van Tuijl,W Van Klei,Van Der Werff,D Kalkman,C (2006). The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial.
Z Khan,C Ferguson,R Jones (1999). -2 and imidazoline receptor agonists.
Brian Prichard,Barrie Graham (2000). I1 Imidazoline Agonists. General Clinical Pharmacology of Imidazoline Receptors.
Spencer Liu,Md (1995). Oral Clonidine Prolongs Lidocaine Spinal Anesthesia in Human Volunteers.
Stephan Strebel,Rg Ju¨,Markus Gurzeler,Armin Schneider,Christoph Aeschbach,Kindler (2004). Small Dose Intrathecal Clonidine and Isobaric Bupivacaine for Orthopedic Surgery: A Dose-Response Study.
Stephen Mannion,Ivan Hayes,Frank Loughnane,Damian Murphy,George Shorten (2005). Intravenous but Not Perineural Clonidine Prolongs Postoperative Analgesia After Psoas Compartment Block with 0.5% Levobupivacaine for Hip Fracture Surgery.
J Howe,J Wang,T Yaksh (1983). Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine..
T Kita,K Kagawa,T Mammoto (2000). Supraspinal, not spinal, -2 adrenoceptors are involved in the anesthetic-sparing and hemodynamic-stabilizing effects of systemic clonidine in rats.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr Prerana Shah. 2014. \u201cUse of Intravenous Clonidine Vs Placebo for Prolonging Spinal Anaesthesia\u201d. Unknown Journal GJMR-I Volume 14 (GJMR Volume 14 Issue I1).

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Journal Specifications

Keywords

anaesthesia bupivacaine clonidine spinal

Submission ReceivedDecember 14, 2013
Peer Review Double Blind
Handling Editor
Accepted December 31, 2013
Published January 15, 2014

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v1.2

Issue date

March 29, 2014

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Article Matrices

Total Score: 102

Country: India

Subject: Uncategorized

Authors: Prerana Nirav Shah, Devanand Pawar (PhD/Dr. count: 0)

View Count (all-time): 170

Total Views (Real + Logic): 4667

Total Downloads (simulated): 2340

Publish Date: 2014 03, Sat

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Total Views: 4667

Total Downloads: 2340

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