Vascular Aging Factors in Individuals with Different Cardiovascular Risk
Objective: Study of vascular aging markers in conjunction with metabolic parameters and the degree of cardiovascular risk (CVR). Materials and methods: The study included 298 patients aged 40 to 69 years old. Parameters of lipid metabolism, immune inflammation, endothelial dysfunction, telomere length, insulin resistance, biological age (BA), and CVR were determined. Differences were deemed statistically significant at p <0.05. Results: Significant changes occur in lipid and carbohydrate metabolism parameters, as well as markers of immune and endothelial inflammation, the degree of intensity of which depends on the CVR degree. During this process, significant changes occur in the length of telomeres, which have a relation with hyperinsulinemia. Telomeres are shorter in more than 50% of patients suffering from even moderate CVR.
