Waldenstromas Macroglobulinema Presenting as Syncope

§ Rutgers Robert Wood Johnson Medical School

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Waldenstromas Macroglobulinema Presenting as Syncope

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Background

Abstract

Syncope is a common complaint usually secondary to neurologic, cardiovascular, or orthostatic causes. However, rare etiologies are possible, implicating a great importance to history, physical examination, and interpretation of laboratory results and diagnostic workup. Waldenstrom’s Macro-globulinema (WM) is a B-cell Lymphoma, hallmarked by an overproduction of IgM. Neurologic manifestations of WM include visual or auditory disturbances, headache, confusion, dizziness, vertigo, stroke and rarely, syncope. Neurologic presentations are a result of hyperviscosity or direct infiltration of malignant cells into the CNS. We present a case of Waldenstrom’s Macroglublinema associated syncope.

References

5 Cites in Article
  1. Pei Lin,L Medeiros (2005). Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia.
  2. S Ansell,R Kyle,C Reeder,R Fonseca,J Mikhael,W Morice (2010). Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines.
  3. Thomas Ritzenthaler,Véronique Leray,Gaël Bourdin,Thomas Baudry,Izabela-Irina Domnisoru,Hervé Ghesquières,Ghislaine Saint Pierre,François Ducray,Claude Guerin (2013). Ventriculitis revealing Bing-Neel syndrome in a patient without Waldenstrom's macroglobulinemia.
  4. Sanchez-Guerrero Scastillo,J (2015). Bing-Neel syndrome: a rare complication of Waldenstrom macroglobulinemia.
  5. S Stone Mbogen (2011). Evidence-based focused review of management of hyperviscosity syndrome.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Ramy Sedhom. 2016. "Waldenstromas Macroglobulinema Presenting as Syncope". Global Journal of Medical Research - F: Diseases GJMR-F Volume 16 (GJMR Volume 16 Issue F5).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-F Classification NLMC Code: WB182
Version of record

v1.2

Issue date
November 23, 2016

Language
English
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Waldenstromas Macroglobulinema Presenting as Syncope

Ramy Sedhom
Ramy Sedhom Rutgers Robert Wood Johnson Medical School