Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA

Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA

Herman S. Cheung

Contact

Carlos M. Carballosa

Contact

David J. Fernandez-Fidalgo

Contact

University of Miami

Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA

Article Fingerprint

ReserarchID

8XY77

Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Nicotine is the main ingredient of smoking cessation therapies and electronic cigarettes. New to the market, electronic cigarettes, which are not regulated by Food and Drug Administration (FDA), have been marketed as the safe and alternative approach to cigarette smoking. Although containing significantly fewer amounts of toxic chemicals, electronic cigarettes, as well as other nicotine replacement therapies, still present additional health hazards due to significant nicotine exposure. The effects of nicotine exposure on musculoskeletal health have been extensively studied, but the mechanisms behind these effects are still unknown. Current research, however, suggests that these effects are mediated by the nicotinic acetylcholine receptors (nAChRs) of the musculoskeletal system. These receptors, which are activated in the presence of nicotine, undergo conformational changes that eventually alter the ionic permeability of their respective membranes.

References

78 Cites in Article

Reference Format

E Albuquerque,E Pereira,M Alkondon,S Rogers (2009). Mammalian nicotinic acetylcholine receptors: From structure to function.
K Alemdaroǧlu,U Tiftikçi,S Iltar,N Aydoǧan,T Kara,D Atlihan,A Sabri Ateşalp (2009). Factors affecting the fracture healing in treatment of tibial shaft fractures with circular external fixator.
D Bartel (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function.
N Benowitz,J Hukkanen,Iii Jacob,P (2009). Nicotine chemistry, metabolism, kinetics and biomarkers.
Neal Benowitz,Peyton Jacob Iii (1993). Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers.
N Benowitz,Iii Jacob,P (2000). Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism.
N Benowitz,Iii Jacob,P Denaro,C Jenkins,R (1991). Stable isotope studies of nicotine kinetics and bioavailability.
Neal Benowitz,Herve Porchet,Lewis Sheiner,Peyton Jacob (1988). Nicotine absorption and cardiovascular effects with smokeless tobacco use: Comparison with cigarettes and nicotine gum.
J Bergström (2004). Tobacco smoking and chronic destructive periodontal disease.
J Boulter,J Connolly,E Deneris,D Goldman,S Heinemann,J Patrick (1987). Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family..
D Brunzell,D Russell,M Picciotto (2003). In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57B1/6J mice.
Thomas Callis,Jian-Fu Chen,Da-Zhi Wang (2007). MicroRNAs in Skeletal and Cardiac Muscle Development.
Stephen Babb,Ann Malarcher,Gillian Schauer,Kat Asman,Ahmed Jamal (2011). Quitting Smoking Among Adults — United States, 2000–2015.
A Chernyavsky,J Arredondo,E Karlsson,I Wessler,S Grando (2005). The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration.
J Choi,J Kim,S Jeong,S Son (2010). Nicotine induces the expression of early growth response-1 in human skin dermal fibroblasts.
Pierre-Jean Corringer,Sonia Bertrand,Jean-Luc Galzi,Anne Devillers-Thiéry,Jean-Pierre Changeux,Daniel Bertrand (1999). Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor.
R Corriveau,S Romano,W Conroy,L Oliva,D Berg (1995). Expression of neuronal acetylcholine receptor genes in vertebrate skeletal muscle during development.
B Conti-Tronconi,K Mclane,M Raftery,S Grando,M Protti (1994). The nicotinic acetylcholine receptor: Structure and autoimmune pathology.
John Dani,Daniel Bertrand (2007). Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System.
M Nosse,S Hartmann,K Trinkaus,V Alt,B Stigler,C Heiss,. Lips,K (1988). Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis.
M Fagerlund,L Eriksson (2009). Current concepts in neuromuscular transmission.
J Fusby,M Kassmeier,V Palmer,G Perry,D Anderson,B Hackfort,. Swanson,P (2010). Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 +:CD8+ Tcell ratios are reversed by smoking cessation: Influence of bone mass on immune cell response to and recovery from smoke exposure.
Jean-Luc Galzi,Anne Devillers-Thiery,Nicolas Hussy,Sonia Bertrand,Jean-Pierre Changeux,Daniel Bertrand (1992). Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.
M Goniewicz,P Hajek,H Mcrobbie (2013). Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: Regulatory implications.
A Ham,W Harris (1971). Repair and transplant of bone.
R Herning,R Jones,N Benowitz,A Mines (1983). How a cigarette is smoked determines blood nicotine levels.
Martin Hoogduijn,Aixin Cheng,Paul Genever (2009). Functional Nicotinic and Muscarinic Receptors on Mesenchymal Stem Cells.
L Huang,U Winzer-Serhan (2006). Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression.
Janne Hukkanen,Pleyton Jacob,Neal Benowitz (2005). Metabolism and Disposition Kinetics of Nicotine.
R Hurst,H Rollema,D Bertrand (2013). Nicotinic acetylcholine receptors: From basic science to therapeutics.
Rami Kallala,Jonathan Barrow,Simon Graham,Nikolaos Kanakaris,Peter Giannoudis (2013). The<i>in vitro</i>and<i>in vivo</i>effects of nicotine on bone, bone cells and fracture repair.
A Kawakita,K Sato,H Makino,H Ikegami,S Takayama,Y Toyama,A Umezawa (2008). Nicotine acts on growth plate chondrocytes to delay skeletal growth through the α7 neuronal nicotinic acetylcholine receptor.
Takeshi Kihara,Shun Shimohama,Hideyuki Sawada,Kazuhiro Honda,Tomoki Nakamizo,Hiroshi Shibasaki,Toshiaki Kume,Akinori Akaike (2001). α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity.
Beom-Su Kim,Su-Jin Kim,Hyung-Jin Kim,Seung-Jin Lee,Yoon-Jeong Park,Jun Lee,Hyung-Keun You (2012). Effects of nicotine on proliferation and osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells.
So Kim,Kyung Kang,Jeong-Chae Lee,Jung Heo (2012). Nicotinic Acetylcholine Receptor α7 and β4 Subunits Contribute to Nicotine-Induced Apoptosis in Periodontal Ligament Stem Cells.
Kristopher Krannitz,Hon Fong,Lawrence Fallat,John Kish (2009). The Effect of Cigarette Smoking on Radiographic Bone Healing After Elective Foot Surgery.
N Laytragoon-Lewin,F Bahram,L Rutqvist,I Turesson,F Lewin (2011). Direct effects of pure nicotine, cigarette smoke extract, swedish-type smokeless tobacco (snus) extract and ethanol on human normal endothelial cells and fibroblasts.
B Lee,N Benowitz,Iii Jacob,P (1987). Influence of tobacco abstinence on the disposition kinetics and effects of nicotine.
H Lee,S Pi,Y Kim,H Kim,S Kim,Y Kim,. Kim,E (2009). Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells.
S Lee,K Kang,S Shin,Y Herr,Y Lee,E Kim (2012). Endoplasmic reticulum stress modulates nicotine‐induced extracellular matrix degradation in human periodontal ligament cells.
Jon Lindstrom (1997). Nicotinic acetylcholine receptors in health and disease.
Ronald Lukas,Jean-Pierre Changeux,Nicolas Le Novère,Edson Albuquerque,David Balfour,Darwin Berg,Daniel Bertrand,Vincent Chiappinelli,Paul Clarke,Allan Collins,John Dani,Sharon Grady,Kenneth Kellar,Jon Lindstrom,Michael Marks,Maryka Quik,Palmer Taylor,Susan Wonnacott (1999). International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits.
L Ma,M Sham,L Zheng,L Cheung (2011). Influence of low-dose nicotine on bone healing.
K Macklin,A Maus,E Pereira,E Albuquerque,B Conti-Fine (1998). Human vascular endothelial cells express functional nicotinic acetylcholine receptors.
J Martin,S Mousa,O Shaker,S Mousa (2009). The multiple faces of nicotine and its implications in tissue and wound repair.
Erin Meyer,Lorise Gahring,Scott Rogers (2002). Nicotine Preconditioning Antagonizes Activity-dependent Caspase Proteolysis of a Glutamate Receptor.
Marı́a-Dolores Miñana,Carmina Montoliu,Marta Llansola,Santiago Grisolı́a,Vicente Felipo (1998). Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons.
Laurent Misery (2004). Nicotine effects on skin: Are they positive or negative?.
A Missias,G Chu,B Klocke,J Sanes,J Merlie (1996). Maturation of the acetylcholine receptor in skeletal muscle: Regulation of the AChR γ-to-ε switch.
L Molander,E Lunell,S Andersson,F Kuylenstierna (1996). Dose released and absolute bioavailability of nicotine from a nicotine vapor inhaler.
Tsz Ng,Carlos Carballosa,Daniel Pelaez,Hoi Wong,Kwong Choy,Chi Pang,Herman Cheung (2013). Nicotine Alters MicroRNA Expression and Hinders Human Adult Stem Cell Regenerative Potential.
M Ojima,T Hanioka,K Tanaka,E Inoshita,H Aoyama (2006). Relationship between smoking status and periodontal conditions: findings from national databases in Japan.
R Papke,J Boulter,J Patrick,S Heinemann (1989). Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes.
R Papke,S Heinemann (1991). The role of the β4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine α3-receptors.
H Park,K Cho,Y Park,T Lee (2011). Chronic nicotine exposure attenuates proangiogenic activity on human umbilical vein endothelial cells.
Yang Park,Taeseung Lee,Jongwon Ha,In Jung,Jung Chung,Sang Kim (2008). Effect of nicotine on human umbilical vein endothelial cells (HUVECs) migration and angiogenesis.
D Perry,M Dávila-García,C Stockmeier,K Kellar (1999). Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies.
M Picciotto,B Caldarone,D Brunzell,V Zachariou,T Stevens,S King (2001). Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications.
Scott Porter,Edward Hanley (2001). The Musculoskeletal Effects of Smoking.
G Portugal,T Gould (2008). Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research.
R Prather,T Tu,C Rolf,J Gorsline (1993). Nicotine pharmacokinetics of nicoderm® (nicotine transdermal system) in women and obese men compared with normal-sized men.
R Resende,A Alves,L Britto,H Ulrich (2008). Role of acetylcholine receptors in proliferation and differentiation of P19 embryonal carcinoma cells.
Suzanne Romano,Roderick Corriveau,Richard Schwarz,Darwin Berg (1997). Expression of the Nicotinic Receptor α7 Gene in Tendon and Periosteum During Early Development.
J Ruiz,D Pelaez,J Dias,N Ziebarth,H Cheung (2012). The effect of nicotine on the mechanical properties of mesenchymal stem cells.
Nina Schneider,Richard Olmstead,Mikael Franzon,Erik Lunell (2001). The Nicotine Inhaler.
I Schraufstatter,R Discipio,S Khaldoyanidi (2009). Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.
Geeta Sharma,Sukumar Vijayaraghavan (2002). Nicotinic receptor signaling in nonexcitable cells.
Y Shen,H Liu,X Ying,S Yang,P Nie,S Cheng,. Xu,H (2013). Dose-dependent effects of nicotine on proliferation and differentiation of human bone marrow stromal cells and the antagonistic action of vitamin C.
D Silva,M Cáceres,R Arancibia,C Martínez,J Martínez,P Smith (2012). Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation.
A Sloan,I Hussain,M Maqsood,O Eremin,M El-Sheemy (2010). The effects of smoking on fracture healing.
M Sopori (2002). Effects of cigarette smoke on the immune system.
R Stevens (1994). Joint abuse liability review of nicotine nasal spray, in FDA Drug Abuse Advisory Committee Background Information.
F Tinti,M Soory (2012). Mechanisms for redox actions of nicotine and glutathione in cell culture, relevant to periodontitis.
N Urakawa,T Nagata,K Kudo,K Kimura,T Imamura (1994). Simultaneous determination of nicotine and cotinine in various human tissues using capillary gas chromatography/mass spectrometry.
Amparo Villablanca (1998). Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro.
L Walker,M Preston,J Magnay,P Thomas,A El Haj (2001). Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture.
T Wallace,D Bertrand (2013). Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex.
X Wang,Y Liu,Q Wang,M Tsuruoka,K Ohta,S Wu,. Inoue,T (2010). Functional expression of α7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Herman S. Cheung. 2014. \u201cNicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA\u201d. Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System GJMR-H Volume 14 (GJMR Volume 14 Issue H1).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 14 Issue H1

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

bone healing Cigarette smoking electronic cigarette muscu nicotine nicotine acetylcholine receptor nicotine replacement therapies wound healing

Submission ReceivedDecember 10, 2013
Peer Review Double Blind
Handling Editor
Accepted January 3, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

June 6, 2014

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 133

Country: United States

Subject: Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System

Authors: Carlos M. Carballosa, David J. Fernandez-Fidalgo, Herman S. Cheung (PhD/Dr. count: 0)

View Count (all-time): 184

Total Views (Real + Logic): 4712

Total Downloads (simulated): 2312

Publish Date: 2014 06, Fri

Monthly Totals (Real + Logic):

Month 1: 24 views
Month 2: 29 views
Month 3: 44 views
Month 4: 52 views
Month 5: 35 views
Month 6: 42 views
Month 7: 29 views
Month 8: 21 views
Month 9: 54 views
Month 10: 56 views
Month 11: 28 views
Month 12: 31 views
Month 13: 24 views
Month 14: 13 views
Month 15: 25 views
Month 16: 19 views
Month 17: 30 views
Month 18: 25 views
Month 19: 35 views
Month 20: 38 views
Month 21: 33 views
Month 22: 18 views
Month 23: 43 views
Month 24: 22 views
Month 25: 41 views
Month 26: 47 views
Month 27: 29 views
Month 28: 32 views
Month 29: 40 views
Month 30: 27 views
Month 31: 38 views
Month 32: 44 views
Month 33: 34 views
Month 34: 45 views
Month 35: 45 views
Month 36: 23 views
Month 37: 33 views
Month 38: 39 views
Month 39: 27 views
Month 40: 36 views
Month 41: 43 views
Month 42: 14 views
Month 43: 33 views
Month 44: 31 views
Month 45: 33 views
Month 46: 20 views
Month 47: 40 views
Month 48: 36 views
Month 49: 30 views
Month 50: 31 views
Month 51: 28 views
Month 52: 26 views
Month 53: 31 views
Month 54: 45 views
Month 55: 38 views
Month 56: 23 views
Month 57: 46 views
Month 58: 33 views
Month 59: 30 views
Month 60: 38 views
Month 61: 25 views
Month 62: 18 views
Month 63: 36 views
Month 64: 29 views
Month 65: 24 views
Month 66: 30 views
Month 67: 32 views
Month 68: 31 views
Month 69: 39 views
Month 70: 34 views
Month 71: 32 views
Month 72: 15 views
Month 73: 38 views
Month 74: 32 views
Month 75: 36 views
Month 76: 41 views
Month 77: 23 views
Month 78: 36 views
Month 79: 31 views
Month 80: 38 views
Month 81: 24 views
Month 82: 28 views
Month 83: 22 views
Month 84: 21 views
Month 85: 47 views
Month 86: 25 views
Month 87: 12 views
Month 88: 36 views
Month 89: 29 views
Month 90: 20 views
Month 91: 15 views
Month 92: 20 views
Month 93: 26 views
Month 94: 29 views
Month 95: 43 views
Month 96: 16 views
Month 97: 34 views
Month 98: 41 views
Month 99: 31 views
Month 100: 29 views
Month 101: 46 views
Month 102: 27 views
Month 103: 17 views
Month 104: 37 views
Month 105: 35 views
Month 106: 22 views
Month 107: 33 views
Month 108: 19 views
Month 109: 31 views
Month 110: 45 views
Month 111: 41 views
Month 112: 33 views
Month 113: 29 views
Month 114: 24 views
Month 115: 31 views
Month 116: 38 views
Month 117: 25 views
Month 118: 22 views
Month 119: 41 views
Month 120: 25 views
Month 121: 38 views
Month 122: 39 views
Month 123: 43 views
Month 124: 37 views
Month 125: 31 views
Month 126: 39 views
Month 127: 27 views
Month 128: 26 views
Month 129: 18 views
Month 130: 28 views
Month 131: 38 views
Month 132: 39 views
Month 133: 29 views
Month 134: 25 views
Month 135: 32 views
Month 136: 21 views
Month 137: 25 views
Month 138: 30 views
Month 139: 23 views
Month 140: 28 views
Month 141: 37 views
Month 142: 34 views
Month 143: 66 views
Month 144: 51 views

Total Views: 4712

Total Downloads: 2312

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]