Bio
Waleed Osama Abdel-Fattah Atta, also known as Waleed O. Atta, is a medical professional based in Egypt. He holds a qualification in General Surgery and Oncology from Assiut University and has been associated with Assiut University. His research interests include Cancer Biology and Pharmacology. He has authored papers on topics such as the effect of monoclonal antibodies conjugation with gallium-containing solamargine as a Warburg effect-based cancer therapeutic strategy, and the usage of nivolumab with a platinum-containing STAT1 molecule for suppressing PD-1/PD-L1 genes in expressing cancer cells.
Educational Journey
Assiut University
General Surgery and Oncology • General Surgery and Oncology
Experience
Affiliations
Global Journal
Fellow
Member since 2021Grants and Awards
Fellow
Global Journal
Research
Usage of Nivolumab – Platinum Containing STAT1 Molecule for Suppression PD-1/PD-L1 Genes in PD-1/PD-L1 Expressing Cancer Cells
Blockage of PD-1 proteins by immune checkpoint inhibitors showed accepted therapeutic effect in cancer. But tumor microenvironment exerts their anti-tumor effect by various mechanisms. Malignant cells have the ability of PD-1/PD-L1 protein oversynthesis which can be a defense action against immune checkpoint inhibitors and immunotherapy. Binding nivolumab with platinum containing STAT1 will be used for reduction of PD-1 genetic level. Nivolumab has the option of endocytosis, while STAT1 is the transcription factor that binds to the DNA specifically PD-1 gene. STAT1 is the activated protein in response to multiple cytokines stimulation of cancer cells, which are the same for increasing PD-1/ PD-L1 upregulation. The used STAT1 in our therapeutic strategy is the activated form and loaded with platinum particles for damaging DNA bases in PD-1 promoter regions upon translocation to the nucleus.STAT1-platinum molecule is connected to nivolumab Fc region by solamargine polymer for selective cancer cell targeting.
Effect of Monoclonal Antibodies Conjugation With Gallium-Containing Solamargine: Warburg Effect- Based Cancer Therapeutic Strategy. Article Review
Therapy by Monoclonal antibodies is considered extremely hoping method for cancer therapy. But cancer cells have variable methods for resistance by multiple genetic mutations. The aim of that article to illustrate tagging monoclonal antibodies by gallium containing solamargine glycoside within the antibody by glycosylation the asparagine of its Fc portion. Malignant cells need to a big extent high carbohydrate content for aerobic glycolysis for cancer progression. Solamargine as a specific glycoside can be diffused easily and effectively into malignant cells with a high degree of specificity. Complexion gallium to solamargine then conjugation into monoclonal antibodies will increase Monoclonal antibody potency and affinity by Warburg effect based mechanism and gallium particles. Gallium can be retained for a long time inside malignant cells. By that method, the monoclonal antibody will be targeted to cancer cells by solamargine, retained gallium particles besides its functioning specific Fab region.
