Bio
Dr. Kashinath R.T. is a biochemist with an MSc in Biochemistry, a PhD in Biochemistry (Medical Faculty), and is a Fellow of the International College of Surgeons (FICS). His research focuses on diabetes, cardiovascular risks, and lipoproteins. He has served as Professor and Head of the Department of Biochemistry at Subbaiah Institute of Medical Sciences & Research Center, and as Director of R&D at SUIMS. He has published 14 papers and has an h-index of 3.
Educational Journey
MSc • Biochemistry
PhD • Biochemistry (Medical Faculty)
Experience
Subbaiah Medical College
2018 - 2021Subbaiah Institute of Medical Sciences & Research Center
Professor & Head of Department
0 - 0 • BiochemistryEditors Role
Reviewer
Global Journal of Medical Research (GJMR)
2012 -Affiliations
International College of Surgeons
Fellow
Member since 0Research
Hyperuricemia in Type 2 Diabetes Mellitus
Recently there has been a growing interest in the association of uric acid levels with hyperglycemia. Insulin deficiency or subnormal functioning of insulin may induce possible alterations in purine nucleotide metabolism, specifically uric acid turnover. Studies have indicated that a close relationship do exists between plasma uric acid levels and glucose utilisation in type 2 diabetes mellitus. Though there are reports showing elevated plasma uric acid levels in type 2 diabetes mellitus but the origin of raised uric acid is still obscure. Hence a study was undertaken to assess the origin of raised plasma uric acid levels in diabetes mellitus. The type 2 diabetic subjects attending the OPD of Subbaiah Medical College Hospital, Purale, Shimoga were randomly selected. A fasting Blood sample was collected and the plasma samples were employed for estimation of glucose, uric acid, adenosine deaminase and 5'-nucleotidase levels. The results indicate a parallel raise in the plasma levels of adenosine deaminase and in 5'-nucleotidase along with plasma uric acid levels in type 2 diabetic subjects suggesting the raised plasma uric acid in type 2 diabetic subjects is due to increased purine catabolism
Plasma Total Amino Acids, Plasma Glutamate and Alanine Levels in Diabetic Subjects
Generally, in fasting state, gluconeogenesis accounts for about 30% of overall hepatic glucose output, the increase in type 2 diabetic subjects may be much more than this level. There is a close relationship between glucose metabolism and amino acid metabolism which is established through transamination reactions. The key amino acid -keto acid pairs involved in transamination reactions are glutamate – α ketoglutarate, aspartate – oxaloacetate and pyruvate - alanine. A study was undertaken to assess the plasma levels of total amino acids, glutamate and alanine in type 2 diabetic subjects. A blood sample (5ml) with heparin as an anticoagulant was collected in the fasting state, from each of the selected normal as well as diabetic subjects. The separated plasma samples were employed for the estimation of total amino acid nitrogen levels, as well as for the estimation of plasma alanineand glutamate levels. The results indicate a significant rise in the plasma levels of total amino acids, alanine & glutamate in type-2 diabetic subjects as well as a significant increase in plasma alanine levels in diabetics of 30- 40 yrs age as compared to diabetics of 41-60yrs of age. These findings suggest an increased availability of glucogenic amino acid precursors for glucose formation may be due to lack of proteolytic suppression of insulin.
