Research
On The Notion of Percentage Nucleotide Concentration of Genome Sequences in Terms of Cellular Automata Evolutions of Adjoints Sequences
This paper proposes a novel concept called “Percentage Nucleotide Concentration of genomes†in terms of cellular automata evolutions of adjoints of Adenine, Thymine, Guanine, and Cytosine. The adjoints of the given a genome sequenceare the characteristic binary string sequences. For example, the adjoint of Adenine of a given genome sequence is a binary string consisting of 0’s and 1’s where 1’s corresponds to the presence of Adenine in the genome sequence. So, one can have four adjoint sequences of Adenine, Thymine, Guanine, and Cytosine corresponding to a given genome sequence. One-dimensional three neighborhood binary value cellular automata rules could be applied to an adjoint sequence and the desired number of evolutions obtained.These rules aredefined by linear Boolean functions and one can have 256 such linear Boolean functions.Nucleotide concentration is computed for an adjoint sequence and its variation evaluated for its successive evolutions based on a cellular automaton rule.
Modeling and Simulation of Genome Evolution Using Linear Boolean Functions Associated with One Dimensional Cellular Automata
Structural and functional behavior of genomes could be studied using one dimensional binaryvalued three neighborhood cellular automata updating rules. These updating rules are linear Boolean functions, and they are applied to the adjoint sequences of adenine, (A), Thymine (T), Guanine (G) and Cytosine (C) corresponding to the characteristic sequence of a genome. This paper proposes the use of linear Boolean functions, and demonstrates the textural or fractal behavior of genome evolution in terms of nucleotide adjoints.
A Novel Approach to Genome Editing Using Cellular Automata Evolutions of Adjoints Sequences
This paper proposes a novel method for genome editing using cellular automata evolutions of adjoints of Adenine, Thymine, Guanine, and Cytosine. The adjoints of the given a genome sequence are the characteristic binary string sequences. For example, the adjoint of Adenine of a given genome sequence is a binary string consisting of 0’s and 1’s where 1’s corresponds to the presence of Adenine in the genome sequence. So, one can have four adjoint sequences of Adenine, Thymine, Guanine, and Cytosine corresponding to a given genome sequence. One-dimensional three neighborhood binary value cellular automata rules can be applied to an adjoint sequence and the desired number of evolutions could be obtained. This rule is defined by a linear Boolean function and one can have 256 such linear Boolean functions. Genome editing is carried out by superimposing the evolved adjoint sequence on the original genome sequence or on its successive evolutions. In this manner, one can have four ways of genome editing using four adjoint sequences and evolutions.
