Research
Detection of the Inhibitory Potential of Psidium Guajava L. Extract in Multidrug-Resistant Corynebacterium Striatum Strains Isolated from Nosocomial Outbreaks
Corynebacterium striatum is an emerging Gram-positive bacillus that presents tropism for thehuman microbiota, however, it has a high probabilityofpresenting a multidrug-resistant (MDR) profile. In addition, severalstudiesindicate its abilityto cause seriousinfections in patients with varying levels of immune compromise. C. striatum samples may present different virulence mechanisms such as; disinfectant tolerance, motility, and bacterial biofilm formation. This work aims to evaluate the antimicrobial activity of the hydroalcoholic extract of Psidium guajava L. on MDR and MDS strains of C. striatum an alternative for treatment. We used the agar disk diffusion method to evaluate the susceptibility of bacterial samples under conditions of treatment with Psidium guajava L.
Varpha-K Prototype: Evolution of Anticoagulant Treatment with Improved Safety and Efficiency
Pharmaceutical chemistry seeks to discover and develop new chemical molecules that can be useful as medicines, in addition to the possibility of improvement in some molecular physicochemical aspect. These modifications cannot alter the pharmacophoric group, which is the chemical functional group responsible for the therapeutic effects (KOROLKOVAS 1982). Thus, our objective was to present the physicochemical aspects related to the association of vitamin K with warfarin molecule (VAR), in order to develop the Varfa-K Prototype, a new drug that has fewer toxic effects, mainly reducing bleeding events caused by VAR. Therefore, we used the methodology of molecular association and insertion of bulky groups. By adding a molecule (vitamin K) to the parent drug and its own antidote against bleeding.
