Immune Associations in Hashimotoas Thyroiditis and Related Disorders
Material and method a) Diagnostic: A. Diagnostic of thyroid immune disease: ATPO and ATG investigation was considered as necessary and were correlated with ultrasound. B. Diagnostic of immune disease. The diagnostic was based on classical guides for every disease. 2. Patients: A. “Classical” Hashimoto thyroiditis (hyper-ATPO-emia, HT) = 1276, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) = 85, C. thyroiditis “sero-negative” (normal ATPO and ATG, pathology diagnosis) = 9, D. idiopathic myxedema (hypothyroidism, no A,B,C) = 76; E. control = 1216 (no antibodies, when hypothyroidism, iatrogenic). b) Statistical analysis: χ2 test for comparing patients data with control data and z-test for comparing proportions. Results a) Immune association – in total: in HT = 237 (18.57%, p << 0.001); in T-ATG = 23 (27.06%, p << 0.001); in “seronegative” = 1 (11.11%, NS); in idiopathic myxedema = 11 (14.47%, p = 0.9, NS); in control: 107 (8.80%). b) Main Immune Associations were with: A. Vitiligo: in HT = 37, p=0.0006; in T-ATG = 2 (p = 0.09); in Control = 11. B. Allergic dermatitis: in HT = 35, p=0.0001; in T-ATG = 2 (p = 0.09). C. Drug allergy: in HT: 27 (p=0.007); in ATG-T: 2. D. Immune ovaritis with precocious menopause: in HT = 16, p=0.009. E. IDDM: in HT: 15 (p= 0.06); F. Allergic rhinitis: in HT = 13 (p = 0.006); G. Biermer anemia: in HT = 12 (p=0.0096). H. Major colagenoses and vasculitis: in HT: 12 vs 8 in control (NS); I. Rheumatoid arthritis: in HT = 8 vs 20 in control (NS). J. Immune enteric diseases: in HT: 10 (p = 0.025); K. Bronchial asthma: in HT: 9 vs 10 in control (NS). L. Alopecia areata: in HT = 8 (p = 0.06); M. Repetitive zona zoster: in HT = 8 (p=0.023); N. Thrombophilia: in HT = 7 vs 3 in control (NS); O. Otosclerosis: in HT = 4 (NS), in TATG = 3 (p << 0.001) vs 2 in controls. P. Multiple sclerosis: in HT: 4 vs 1 in controls (NS). Q. Corticosuprarenal insufficiency: in HT: 4 (p = 0.05). c) Multiple associations (HT/T-ATG and
