Motor Disorders Related to Parkinson and Dopamine Evil

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Gessica Monique Rocha De Brito
Gessica Monique Rocha De Brito
2
Sara Raquel Garcia De Souza
Sara Raquel Garcia De Souza

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Parkinson’s disease is a neurodegenerative disease characterized by dopamine depletion, death of the dopaminergic neurons of the substantia nigra of the nigrostriatal pathway and presence of neurofibrillary inclusion in the active neurons. The black substance is interconnected with all regions of the brain, they receive glutamatergic innervations and send direct and indirect projections, modulating the activity of the dopaminergic neurons, so the loss of dopamine in the striatum causes monoaminergic chemical changes leading to the increase and decrease of neuronal activity in the motor areas of the cerebral cortex. This study aims to understand the relationship of dopaminergic neurons to clinical symptoms in Parkinson’s disease, to investigate physiological dysfunction and to point out the morphological alterations of the central nervous system.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Gessica Monique Rocha De Brito. 2026. \u201cMotor Disorders Related to Parkinson and Dopamine Evil\u201d. Global Journal of Medical Research - A: Neurology & Nervous System GJMR-A Volume 23 (GJMR Volume 23 Issue A2): .

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Neurodegenerative research on Parkinson's and dopamine receptors.
Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-A Classification: NLM: WL 359, QV 140
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v1.2

Issue date

June 2, 2023

Language

English

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Parkinson’s disease is a neurodegenerative disease characterized by dopamine depletion, death of the dopaminergic neurons of the substantia nigra of the nigrostriatal pathway and presence of neurofibrillary inclusion in the active neurons. The black substance is interconnected with all regions of the brain, they receive glutamatergic innervations and send direct and indirect projections, modulating the activity of the dopaminergic neurons, so the loss of dopamine in the striatum causes monoaminergic chemical changes leading to the increase and decrease of neuronal activity in the motor areas of the cerebral cortex. This study aims to understand the relationship of dopaminergic neurons to clinical symptoms in Parkinson’s disease, to investigate physiological dysfunction and to point out the morphological alterations of the central nervous system.

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Motor Disorders Related to Parkinson and Dopamine Evil

Gessica Monique Rocha De Brito
Gessica Monique Rocha De Brito
Sara Raquel Garcia De Souza
Sara Raquel Garcia De Souza

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