Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA

Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA

Herman S. Cheung

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Carlos M. Carballosa

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David J. Fernandez-Fidalgo

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1 University of Miami, Coral Gables, FL

GJMR Volume 14 Issue H1

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Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA Banner

Nicotine is the main ingredient of smoking cessation therapies and electronic cigarettes. New to the market, electronic cigarettes, which are not regulated by Food and Drug Administration (FDA), have been marketed as the safe and alternative approach to cigarette smoking. Although containing significantly fewer amounts of toxic chemicals, electronic cigarettes, as well as other nicotine replacement therapies, still present additional health hazards due to significant nicotine exposure. The effects of nicotine exposure on musculoskeletal health have been extensively studied, but the mechanisms behind these effects are still unknown. Current research, however, suggests that these effects are mediated by the nicotinic acetylcholine receptors (nAChRs) of the musculoskeletal system. These receptors, which are activated in the presence of nicotine, undergo conformational changes that eventually alter the ionic permeability of their respective membranes.

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Herman S. Cheung. 2014. \u201cNicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA\u201d. Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System GJMR-H Volume 14 (GJMR Volume 14 Issue H1): .

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GJMR Volume 14 Issue H1
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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

bone healing Cigarette smoking electronic cigarette muscu nicotine nicotine acetylcholine receptor nicotine replacement therapies wound healing

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Submission ReceivedDecember 10, 2013
RevisedDecember 10, 2013
Peer Review Double Blind
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Accepted January 3, 2014
Published January 15, 2014

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June 6, 2014

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Country: United States

Subject: Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System

Authors: Carlos M. Carballosa, David J. Fernandez-Fidalgo, Herman S. Cheung (PhD/Dr. count: 0)

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