Effective water management is crucial for industrial operations to minimize freshwater consumption and wastewater discharge. This paper presents a comprehensive approach for optimizing water network design in the presence of multiple contaminants. The proposed methodology incorporates regeneration, reuse, and regeneration-recycle strategies to achieve optimal water usage and contaminant removal. The effectiveness of the proposed approach is demonstrated through case studies involving industrial processes with diverse contaminant profiles. The results show significant reductions in freshwater consumption and wastewater generation compared to conventional designs. By comparing a water network design without any regeneration methods to one that incorporates regeneration techniques, it is evident that the amount of freshwater required is significantly higher in the network without regeneration. The inclusion of regeneration strategies, such as reuse and regeneration-recycle, allows for the treatment and recirculation of process water streams, thereby reducing the demand for costly and resource-intensive freshwater intake. The key difference lies in the ability of the regeneration-based network to efficiently manage contaminant levels and enable the reutilization of water within the system. Without regeneration, the water network would need to rely solely on freshwater makeup to dilute contaminants, leading to higher freshwater consumption. In contrast, the regeneration-enabled network can selectively remove contaminants and reintroduce the treated water back into the process, significantly decreasing the overall freshwater requirements, for example, The paper’s first case study demonstrates that the fresh water consumption in the processes without regeneration is 112.9 tons per hour. However, by implementing regeneration in the same processes, the fresh water consumption decreases to 59.7 tons per hour. This comparison highlights the significant advantages of incorporating regeneration strategies into water network design. By optimizing the integration of treatment technologies and water recirculation pathways, industrial facilities can achieve substantial reductions in freshwater usage and minimize their environmental impact through more sustainable water management practices. This work provides a valuable decision-making tool for industrial water system designers and managers, facilitating the implementation of advanced water minimization techniques and promoting the adoption of circular economy principles in water resource management.