Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review

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David G. Morrison
David G. Morrison

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Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review Banner
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53-year-old lady presented with progressively worsening loss of voice. Over time she could only be heard upon speaking directly into the ears of her family or physicians. She lost her job as a receptionist due to her loss of voice. She was still on adjuvant treatment for breast cancer. She underwent CT/PET, ENT consultation and a battery of paraneoplastic antibody tests. ENT consultation confirmed vocal cord paralysis. ENT exam and CT/PET found no evidence of vocal cord mass or any lesion compressing the laryngeal nerves. No mass was found in the superior mediastinum. She had a positive antibody test for anti-acetylcholine receptors. Treatment with pyridostigmine reversed her vocal cord paralysis. This is the first report of a patient with breast cancer associated paraneoplastic myasthenia gravis syndrome.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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David G. Morrison. 2026. \u201cParaneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review\u201d. Global Journal of Medical Research - A: Neurology & Nervous System GJMR-A Volume 23 (GJMR Volume 23 Issue A1): .

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A medical research article on paraneoplastic syndromes presenting with breast cancer and their implications.
Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-A Classification: DDC Code: 616.7442 LCC Code: RC935.M8
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v1.2

Issue date

February 8, 2023

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English

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53-year-old lady presented with progressively worsening loss of voice. Over time she could only be heard upon speaking directly into the ears of her family or physicians. She lost her job as a receptionist due to her loss of voice. She was still on adjuvant treatment for breast cancer. She underwent CT/PET, ENT consultation and a battery of paraneoplastic antibody tests. ENT consultation confirmed vocal cord paralysis. ENT exam and CT/PET found no evidence of vocal cord mass or any lesion compressing the laryngeal nerves. No mass was found in the superior mediastinum. She had a positive antibody test for anti-acetylcholine receptors. Treatment with pyridostigmine reversed her vocal cord paralysis. This is the first report of a patient with breast cancer associated paraneoplastic myasthenia gravis syndrome.

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Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review

David G. Morrison
David G. Morrison

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